重组牛碱性成纤维细胞生长因子在白内障超声乳化术后的应用效果OA

Objective:To explore the application effect of Levofloxacin,Tobramycin Dexamethasone Eye Drops combined with Recombinant Bovine Basic Fibrolast Growth Factor in patients after cataract phacoemulsification surgery.Method:A total of 80 patients who underwent cataract phacoemulsification surgery in the Department of Ophthalmology and Otorhinolaryngology of Ji'an City First People's Hospital from January 2020 to December 2022 were retrospectively studied.They were divided into a control group and an experimental group according to different treatment methods,with 40 patients in each group.The control group was treated with Levofloxacin and Tobramycin Dexamethasone Eye Drops,while the experimental group was treated with Levofloxacin,Tobramycin Dexamethasone Eye Drops combined with Recombinant Bovine Basic Fibrolast Growth Factor Eye Drops.The eye symptoms of the patients before and after treatment were evaluated using the symptom evaluation for eye dryness(SPEED)score and the fluorescein staining of the cornea(FLS)score.By comparing the levels of nitric oxide(NO),superoxide dismutase(SOD),catalase(CAT)and total antioxidant capacity(TAC)in the serum of patients before and after treatment,the antioxidant indicators were analyzed.Levels of interleukin-8(IL-8),IL-6 and tumor necrosis factor-α(TNF-α)were also determined to compare serum inflammatory factor levels.The incidence of adverse reactions such as irritation,pain and itching in the eyes during medication use was also compared.Result:The SPEED and FLS scores of the experimental group were significantly lower than those of the control group after treatment,the differences were statistically significant(P<0.05).After treatment,the NO level in the experimental group was lower compared to the control group,while SOD,CAT,and TAC levels were higher,serum inflammatory factors levels were also significantly lower in the experimental group after treatment compared to the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions during medication use in the experimental group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The use of Levofloxacin,Tobramycin Dexamethasone Eye Drops combined with Recombinant Bovine Basic Fibrolast Growth Factor can help improve the postoperative eye condition of the patients,enhance the antioxidant indicators,reduce the levels of inflammatory factors,and decrease the incidence of adverse reactions during medication use.It has significant clinical application value.