三氟甲基取代1,1-二芳基烷烃衍生物的合成:光诱导CF3Br参与的碳碳双键三氟甲基/芳基化反应OA北大核心CSTPCD

A synergistic catalytic strategy combining photocatalysis and transition metal catalysis was employed to achieve the carbon carbon double bond trifluoromethyl/arylation reaction in which the inexpensive and readily available bromotrifluoromethane and aromatic amines were used as substrates.A series of potentially biologically active CF3-substituted 1,1-diaryl alkane derivatives was synthesized.This work explores the possibility of aromatic amines as arylation reagents,enriches the types of arylation reagents,clarifies the conditions for the arylation process and explores the reaction mechanism.This method has the characteristics of simple operation,low cost and easy availability,providing a concise and effective approach for the synthesis of trifluoromethyl substituted 1,1-diaryl alkanes derivatives.