高等学校化学学报2024，Vol.45Issue(5)：55-63,9.DOI:10.7503/cjcu20240048
三氟甲基取代1,1-二芳基烷烃衍生物的合成:光诱导CF3Br参与的碳碳双键三氟甲基/芳基化反应
Photoinduced Trifluoromethyl/arylation Reaction of Carbon Carbon Double Bond Involving CF3Br for the Synthesis of CF3-substituted 1,1-Diaryl Alkane Derivatives
摘要
Abstract
A synergistic catalytic strategy combining photocatalysis and transition metal catalysis was employed to achieve the carbon carbon double bond trifluoromethyl/arylation reaction in which the inexpensive and readily available bromotrifluoromethane and aromatic amines were used as substrates.A series of potentially biologically active CF3-substituted 1,1-diaryl alkane derivatives was synthesized.This work explores the possibility of aromatic amines as arylation reagents,enriches the types of arylation reagents,clarifies the conditions for the arylation process and explores the reaction mechanism.This method has the characteristics of simple operation,low cost and easy availability,providing a concise and effective approach for the synthesis of trifluoromethyl substituted 1,1-diaryl alkanes derivatives.关键词
光催化/三氟溴甲烷/三氟甲基/芳基化/1,1-二芳基烷烃衍生物Key words
Photocatalysis/Trifluorobromomrthane/Trifluoromethyl/arylation/1,1-Diaryl alkane derivative分类
化学化工引用本文复制引用
马然松,毕吉利,胡雨来..三氟甲基取代1,1-二芳基烷烃衍生物的合成:光诱导CF3Br参与的碳碳双键三氟甲基/芳基化反应[J].高等学校化学学报,2024,45(5):55-63,9.基金项目
国家自然科学基金(批准号:22061037,21662030)资助. Supported by the National Natural Science Foundation of China(Nos.22061037,21662030). （批准号:22061037,21662030）
