华侨大学学报（自然科学版）2024，Vol.45Issue(3)：394-416,23.DOI:10.11830/ISSN.1000-5013.202311012
Comamonas kerstersii细菌致病性的基因组分析
Genomic Insights of Pathogenicity of Comamonas kerstersii
摘要
Abstract
To achieve better management of Comamonas kerstersii(C.kerstersii)infections,the aim was to understand its virulence and pathogenicity by analyzing the virulence factor genes(VFGs)in the genome of C.kerstersii 121606.The genome was sequenced previously,and the VFGs were predicted by BLAST search-ing through the VFDB database.The results showed that C.kerstersii contained a large number of VFGs,some of which were exemplified to correlate to the survival and growth in humans,and the pathogenicity of C.kerstersii in the gastrointestinal tract and lungs.Genomic analysis revealed that C.kerstersii might be an intracellular pathogen.The harbored VFGs were conducive to explaining its virulence and pathogenicity in gas-trointestinal tract and lung infections reported in the literature or encountered in clinic.The data also provided ideal targets for novel antibiotic and vaccine development for the therapy of C.kerstersii infections.关键词
Comamonas kerstersii/毒力因子基因/致病性/细胞内病原体/胃肠道感染/肺部感染Key words
Comamonas kerstersii/virulence factor gene/pathogenicity/intracellular pathogen/gastrointesti-nal tract infection/lung infection分类
生物科学引用本文复制引用
王慧,明德松,王明席..Comamonas kerstersii细菌致病性的基因组分析[J].华侨大学学报（自然科学版）,2024,45(3):394-416,23.基金项目
福建省厦门南方海洋研究中心科研资金资助项目(14GYY008NF08) （14GYY008NF08）
方树福堂基金会和方润华基金会资助项目(14X30127) （14X30127）
