解放军医学杂志2024，Vol.49Issue(4)：380-386,7.DOI:10.11855/j.issn.0577-7402.2403.2023.1031
2型糖尿病患者血清铁蛋白水平与体脂分布的相关性分析
Association between serum ferritin levels and body fat distribution in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To explore the relationship between serum ferritin levels and body fat distribution in patients with type 2 diabetes mellitus(T2DM).Methods A retrospective analysis was conducted on 151 patients with T2DM who were hospitalized in the Department of Endocrinology of the First Hospital of Lanzhou University from June to November 2020,and all the patients were divided into high serum ferritin(n=50)and normal serum ferritin(n=101)groups according to their serum ferritin levels.The visceral fat area(VFA),subcutaneous fat area(SFA),liver fat,height,weight and waist circumference(WC)were measured,as well as blood glucose,lipid indexes,body mass index(BMI)and visceral adiposity index(VAI)were also calculated.t-test or nonparametric test was used to compare the differences between the two groups,and the relationship between serum ferritin levels and body fat distribution was analyzed by Pearson or Spearman correlation analysis,multiple linear regression and logistic regression.Results The VAI and WC were significantly higher in high serum ferritin group[3.13(2.16,4.58)and(96.66±7.78)cm]than in normal serum ferritin group[2.66(1.66,3.81)and(91.96±9.75)cm,P<0.05].The prevalence of central obesity and dyslipidemia was higher in high serum ferritin group(88.0%and 90.0%)than in normal serum ferritin group(68.3%and 75.2%);and the composition ratios of poor glycemic control and insulin resistance(96.0%and 62.0%)were also higher than in normal serum ferritin group(78.2%and 40.6%)(P<0.05),there were no statistically significant differences in BMI,VFA,and SFA levels,as well as antidiabetic drug use and chronic complications of diabetes mellitus between the two groups(P>0.05).Serum ferritin levels in T2DM patients were positively correlated with VAI,WC,triglyceride(TG),fasting blood glucose(FPG),HbA1c,dyslipidemia and serum creatinine(r=0.171,0.207,0.187,0.243,0.270,0.162,0.162;P<0.05),and negatively correlated with age,sex and diabetes course(r=-0.191,-0.434,-0.352;P<0.05).Multivariate linear regression analysis showed that in male T2DM patients,duration of diabetes and FPG were risk factors for increased levels of serum ferritin.However,WC and VAI did not significantly affect serum ferritin levels.In female patients with T2DM,the course of diabetes,TG and VAI were the factors influencing serum ferritin(P<0.05).Conclusion Dyslipidemia and visceral fat accumulation are risk factors for elevated serum ferritin levels in female T 2DM patients.关键词
糖尿病,2型/血清铁蛋白/体脂分布/内脏肥胖指数/胰岛素抵抗Key words
diabetes mellitus,type 2/serum ferritin/body fat distribution/visceral obesity index/insulin resistance分类
医药卫生引用本文复制引用
陈重阳,吕小羽,赵阳婷,刘露霞,王亚雯,李凯,刘靖芳..2型糖尿病患者血清铁蛋白水平与体脂分布的相关性分析[J].解放军医学杂志,2024,49(4):380-386,7.基金项目
This work was supported by the National Natural Science Foundation of China(81960155),the Natural Science Foundation of Gansu Province(20JR10RA690),and the Internal Hospital Foundation of the First Hospital of Lanzhou University(ldyyyn2020-01) 国家自然科学基金(81960155) （81960155）
甘肃省自然科学基金(20JR10RA690) （20JR10RA690）
兰州大学第一医院院内基金(ldyyyn2020-01) （ldyyyn2020-01）
