水产学报2024，Vol.48Issue(4)：12-21,10.DOI:10.11964/jfc.20221213859
鱼类鼻黏膜相关淋巴组织的研究进展
Advances in the study of nasal-associated lymphoid tissue in fish
摘要
Abstract
The mucosa-associated lymphoid tissue is the first line of defense against pathogens in fish.In recent years,the nasal-associated lymphoid tissue(NALT)of fish has attracted worldwide attention from researchers,and has proved to be an important site for antigen recognition and initiation of mucosal immune response in olfactory organs.NALT exerts a rapid local immune response following bacterial,viral and parasitic infections.Intranasal inoculation of fish targeting NALT can provide excellent immune protection.However,the complex network of cells and molecules in NALT and their interaction mechanisms are still largely unknown.Here,the latest progress in studies on the structure and function of olfactory organs,cellular and molecular networks and immune response of NALT,as well as response to intranasal inoculation and its immunoprotective effect on fish are reviewed.This information will promote understanding of the immune defense mechanism exerted by fish NALT locally in the mucosa,which will benefit the design and development of novel mucosal vaccines.关键词
鱼类/鼻黏膜相关淋巴组织(NALT)/黏膜免疫/嗅觉器官/鼻内接种疫苗Key words
fish/nasal-associated lymphoid tissue(NALT)/mucosal immunity/olfactory organs/intranasal vac-cination分类
农业科技引用本文复制引用
绳秀珍,王锦诚,唐小千,邢婧,迟恒,战文斌..鱼类鼻黏膜相关淋巴组织的研究进展[J].水产学报,2024,48(4):12-21,10.基金项目
国家自然科学基金(32273163,31730101,31872599) （32273163,31730101,31872599）
山东省泰山学者特聘专家项目 National Natural Science Foundation of China(32273163,31730101,31872599) （32273163,31730101,31872599）
Taishan Scholar Program of Shandong Province （）
