鱼类白介素10的研究进展OA北大核心CSTPCD
Research progress on fish interleukin 10
白介素 10(IL-10)是能够参与机体免疫的一种多功能细胞因子,由单核细胞、巨噬细胞等多种免疫细胞分泌,在肿瘤、感染、免疫缺陷等多种疾病的发生发展过程中发挥着重要的调节作用.多种硬骨鱼IL-10 基因被克隆表达,被证实具有免疫调节作用,目前已有不少关于鱼类IL-10 的生物活性、作用机制、调节机制的研究.本文根据已有报道,从鱼类IL-10 的基因结构、转录表达、来源与进化、生物学活性及功能、鱼类IL-10 受体及信号通路等 5 个方面进行了综述,为鱼类IL-10 的研究与应用提供依据.
Interleukin 10(IL-10)is a multifunctional cytokine that participates in the immunity of the body.It is secreted by various immune cells such as monocytes and macrophages,and plays an important role in the develop-ment of various diseases such as tumor,infection and immune diseases.A variety of scleractinian fish IL-10 has been clonally expressed and has shown immunomodulatory effects,and there are a number of studies on the biolo-gical activity,mechanism of action,and regulatory mechanism of IL-10 in fish.To provide a reference for future studies and applications of fish IL-10,a literature review is conducted in terms of its genetic structure,transcrip-tional expression,origin and evolution,biological activities and functions,as well as fish IL-10 receptor and sig-naling pathway.
黎秋男;李书含;周永恒;耿毅;黄小丽;陈德芳;欧阳萍
四川农业大学动物医学院,四川成都 611130四川农业大学动物科技学院,四川成都 611130
水产学
白介素10(IL-10)鱼类白介素10(fIL-10)病毒白介素10(vIL-10)生物学活性
interleukin 10(IL-10)fish interleukin 10(fIL-10)viral interleukin 10(vIL-10)biological activity
《水产学报》 2024 (004)
22-32 / 11
国家自然科学基金(32102844);四川省国际科技创新合作项目(2020YFH0156);成都市科技局项目(2022YF0501021SN) National Natural Science Foundation of China(32102844);Sichuan International Science and Technology Innovation Cooperation Project(2020YFH0156);Chengdu Science and Technology Bureau Project(2022YF0501021SN)
评论