药学研究2024，Vol.43Issue(4)：352-358,7.DOI:10.13506/j.cnki.jpr.2024.04.008
从化妆品监管科学角度探讨类器官及器官芯片的发展现状、趋势与启示
Discussion of the development status,trend and enlightenment of organoids and organ-on-chips from the perspective of regulatory science of cosmetics
摘要
Abstract
In recent years,new complex in vitro models such as organoids and organ-on-chips have emerged at the forefront of international technology and research,gradually being applied to drug and cosmetic research,development,and supervision while attracting considerable attention.This article briefly explains the basic concepts,development history,and technical characteristics of organoids and organ-on-chips.It then provides examples of their application in safety and effica-cy testing of cosmetic ingredients.Finally,combining domestic and international cosmetic regulations,it looks forward to fu-ture trends using organoids and organ-on-chips to improve the efficiency of cosmetic ingredient research and support regu-latory decision-making.Additionally,it proposes regulatory suggestions for the application of this type of new technology from a perspective of regulatory science with an aim to provide technical reserves for cosmetic regulation that aligns with China's situation and promote the transformation of innovative achievements in scientific research into practical regulatory tools.关键词
类器官/器官芯片/化妆品/原料/安全性/功效性/监管科学Key words
Organoids/Organ-on-chips/Cosmetics/Ingredients/Safety/Efficacy/Regulatory science分类
药学引用本文复制引用
林铌,张凤兰,余振喜,王钢力,路勇..从化妆品监管科学角度探讨类器官及器官芯片的发展现状、趋势与启示[J].药学研究,2024,43(4):352-358,7.基金项目
国家重点研发计划项目(No.2022YFF0711100) （No.2022YFF0711100）
中国食品药品检定研究院中青年发展研究基金(No.2022C1) （No.2022C1）
