2019～2021年河南省患儿血培养分离菌分布及耐药性分析OA

Objective:The study aimed to investigate the distribution and antibiotic resistance profile of isolated Bacteria of the blood samples,and provide reasonable rationale for drug utilization for clinical prevention and treatment of bloodstream infections.Methods:WHONET V5.6(software)was applied to analyze the distribution and antibiotic resistance of bacteria isolated from blood cultures of pediatric patients reported by 221 units of Clinical Microbiology Alliance of Henan Province from 2019 to 2021.Results:A total of 10 901 bacteria isolates were collected from blood samples of pediatric patients from 2019 to 2021,among which gram-positive bacteria and gram-negative bacteria accounted for 73.1%and 26.9%,respectively.Coagulase-negative staphylococcus ranked the top,and the top five are coagulase-negative staphylococcus,Staphylococcus aureus,Escherichia coli,Streptococcus pneumoniae and Klebsiella pneumoniae.The prevalence of methicillin-resistant Staphylococcus aureus(MRSA)and penecillin resistant Streptococcus pneumonia(PRSP)was 43.0%and 2.3%,respectively.The resistance rates of Escherichia coli to imipenem and meropenem were 2.2%and 2.3%,while 30.4%and 28.9%for Klebsiella pneumoniae.The resistance rates of Enterobacteriaceae strains in the tertiary hospitals was significantly higher than that in the secondary hospitals.Conclusion:The main isolated bacteria from blood culture of pediatric patients in Henan Province are Gram-positive bacteria.The detection rate of MRSA in the secondary and the tertiary hospitals was relatively high.The resistance rate of Klebsiella pneumoniae to carbapenems in blood samples of pediatric patients showed a gradual downward trend,but it was still at a high level with tertiary hospitals was significantly higher than secondary hospitals.