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2019～2021年河南省患儿血培养分离菌分布及耐药性分析

王健郭利敏赵亮孟高攀田育佼阙蔚鹏郭坤山秦辉孙瑞华张晓蕾胡冬梅李轶张燕李玉霞王彦斌郭瑞娟孟玉娟常军玲张晓黎熊玲玲马冰马琼韩云港高远陈甲李姝郭长城

中国合理用药探索2024，Vol.21Issue(4)：53-62,10.

中国合理用药探索2024，Vol.21Issue(4)：53-62,10.DOI:10.3969/j.issn.2096-3327.2024.04.008

2019～2021年河南省患儿血培养分离菌分布及耐药性分析

Distribution and Antibiotic Resistance Analysis of Blood Culture Isolated Bacteria of Pediatric Patients in Henan Province from 2019 to 2021

王健 ¹郭利敏 ²赵亮 ³孟高攀 ⁴田育佼 ⁵阙蔚鹏 ⁶郭坤山 ⁷秦辉 ⁸孙瑞华 ⁹张晓蕾 ¹⁰胡冬梅 ¹¹李轶 ¹²张燕 ¹¹李玉霞 ¹³王彦斌 ¹⁴郭瑞娟 ¹⁵孟玉娟 ¹⁶常军玲 ¹⁷张晓黎 ¹⁸熊玲玲 ¹⁹马冰 ¹²马琼 ¹²韩云港 ²⁰高远 ²¹陈甲 ²¹李姝 ²²郭长城²³

作者信息

1. 平煤神马集团总医院检验科,平顶山 467000
2. 新乡市中心医院,新乡 453000
3. 周口市中心医院,周口 466000
4. 河南省第二人民医院,郑州 451191
5. 南阳市中心医院,南阳 473005
6. 河南省儿童医院,郑州 450012
7. 许昌市中心医院,许昌 461000
8. 郑州颐和医院,郑州 450018
9. 黄河三门峡医院,三门峡 472000
10. 濮阳市妇幼保健院,濮阳 457000
11. 驻马店市第一人民医院,驻马店 463000
12. 河南省人民医院,郑州 450003
13. 河南大学淮河医院,开封 475000
14. 鹤煤总医院,鹤壁 458000
15. 濮阳市人民医院,濮阳 457000
16. 郑州大学附属洛阳中心医院,洛阳 471000
17. 漯河市中心医院,漯河 462000
18. 商丘市立医院,商丘 476000
19. 信阳市中医院,信阳 464000
20. 河南省胸科医院,郑州 450008
21. 永城市人民医院,商丘 476600
22. 沁阳市人民医院,焦作 454550
23. 黄河中心医院,郑州 450003
折叠

摘要

Abstract

Objective:The study aimed to investigate the distribution and antibiotic resistance profile of isolated Bacteria of the blood samples,and provide reasonable rationale for drug utilization for clinical prevention and treatment of bloodstream infections.Methods:WHONET V5.6(software)was applied to analyze the distribution and antibiotic resistance of bacteria isolated from blood cultures of pediatric patients reported by 221 units of Clinical Microbiology Alliance of Henan Province from 2019 to 2021.Results:A total of 10 901 bacteria isolates were collected from blood samples of pediatric patients from 2019 to 2021,among which gram-positive bacteria and gram-negative bacteria accounted for 73.1%and 26.9%,respectively.Coagulase-negative staphylococcus ranked the top,and the top five are coagulase-negative staphylococcus,Staphylococcus aureus,Escherichia coli,Streptococcus pneumoniae and Klebsiella pneumoniae.The prevalence of methicillin-resistant Staphylococcus aureus(MRSA)and penecillin resistant Streptococcus pneumonia(PRSP)was 43.0%and 2.3%,respectively.The resistance rates of Escherichia coli to imipenem and meropenem were 2.2%and 2.3%,while 30.4%and 28.9%for Klebsiella pneumoniae.The resistance rates of Enterobacteriaceae strains in the tertiary hospitals was significantly higher than that in the secondary hospitals.Conclusion:The main isolated bacteria from blood culture of pediatric patients in Henan Province are Gram-positive bacteria.The detection rate of MRSA in the secondary and the tertiary hospitals was relatively high.The resistance rate of Klebsiella pneumoniae to carbapenems in blood samples of pediatric patients showed a gradual downward trend,but it was still at a high level with tertiary hospitals was significantly higher than secondary hospitals.

关键词

儿童/血流感染/血培养/耐药性/病原菌

Key words

children/bloodstream infection/blood culture/antimicrobial resistance/pathogen

分类

医药卫生

引用本文复制引用

王健,郭利敏,赵亮,孟高攀,田育佼,阙蔚鹏,郭坤山,秦辉,孙瑞华,张晓蕾,胡冬梅,李轶,张燕,李玉霞,王彦斌,郭瑞娟,孟玉娟,常军玲,张晓黎,熊玲玲,马冰,马琼,韩云港,高远,陈甲,李姝,郭长城..2019～2021年河南省患儿血培养分离菌分布及耐药性分析[J].中国合理用药探索,2024,21(4):53-62,10.

基金项目

2023年度河南省医学科技攻关计划联合共建项目(LHGJ20230021) （LHGJ20230021）

中国合理用药探索

ISSN：2096-3327

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