左乙拉西坦联合奥卡西平、丙戊酸钠对良性癫痫伴中央颞区棘波合并睡眠中癫痫性电持续状态患儿临床症状、认知功能的影响OA
Effects of Levetiracetam in Combination with Oxcarbazepine and Sodium Valproate on Clinical Symptoms and Cognitive Function in Children with Benign Epilepsy with Central Temporal Spikes Combined with Electrical Status Epilepticus of Sleep
目的:探究左乙拉西坦联合奥卡西平、丙戊酸钠对良性癫痫伴中央颞区棘波(BECT)合并睡眠中癫痫性电持续状态(ESES)患儿临床症状、认知功能的影响.方法:选取2020年4月～2022年4月在某院接受治疗的100例BECT合并ESES患儿作为研究对象,采用随机数字表法分为对照组和观察组,每组50例.对照组给予奥卡西平和丙戊酸钠,而观察组在对照组治疗基础上加用左乙拉西坦,比较两组临床疗效、治疗前后脑电图改善情况及脑电活动情况,并对患儿治疗前后的认知情况进行评价,记录患儿在治疗期间的不良反应发生情况.结果:治疗后,观察组患儿的治疗有效率(92.00%)高于对照组(76.00%,P<0.05).观察组患儿脑电图改善总有效率(74.00%)高于对照组(46.00%,P<0.05).两种治疗方案均可影响患儿的脑电波活动,特别是在α、β、θ、δ波段,且与对照组相比,观察组患者在这些波段的变化更为显著(P<0.05).治疗前,两组在操作智商、全量表智商、言语智商方面的得分无统计学差异(P>0.05);治疗后,观察组各评分均升高,且优于对照组(P<0.05).两组患儿不良反应发生率比较无统计学差异(P>0.05).结论:与奥卡西平联合丙戊酸钠的治疗方案比较,左乙拉西坦联合奥卡西平和丙戊酸钠治疗儿童BECT合并ESES的疗效更优,能够有效提高患儿的治疗有效率和脑电图改善总有效率,提高患儿的认知功能.
Objective:To investigate the effects of levetiracetam in combination with oxcarbazepine and sodium valproate on clinical symptoms and cognitive function in children with benign epilepsy with central temporal spikes(BECT)combined with electrical status epilepticus of sleep(ESES).Methods:100 children with BECT combined with ESES who were treated in a hospital from April 2020 to April 2022 were selected for the study,and were assigned into a control group and an observation group using the randomized numerical table method,with 50 cases in each group.Oxcarbazepine and sodium valproate were given to the control group,while levetiracetam was added to the treatment of the control group in the observation group.The clinical efficacy,improvement of electroencephalogram(EEG)and electroencephalographic activity before and after the treatment were compared between the two groups,and the cognitive status of the children before and after the treatment was evaluated.The occurrence of adverse reactions during the treatment was recorded.Results:Following treatment,the response rate in the observation group was(92.00%)higher than that of the control group(76.00%,P<0.05).The overall response rate of EEG improvement in the observation group was(74.00%)higher than that of the control group(46.00%,P<0.05).Both treatment regimens can affect the children's EEG wave activity,especially in the α,β,θ and δ bands;and compared with the control group,patients in the observation group showed more significant changes in these bands(P<0.05).Before treatment,there was no statistically significant difference between the scores of the two groups in terms of operational IQ,full scale IQ,and verbal IQ(P<0.05);after treatment,all scores of the observation group were elevated and better than those of the control group(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion:Compared with the treatment regimen of oxcarbazepine in combination with sodium valproate,the efficacy of levetiracetam in combination with oxcarbazepine and sodium valproate in the treatment of BECT combined with ESES in children was superior,which was able to effectively increase the treatment efficiency and the overall response in terms of EEG improvement,and improve the cognitive function of the children.
田增春;张淼;梁璐
南阳市中心医院,南阳 473000
临床医学
左乙拉西坦奥卡西平丙戊酸钠良性癫痫伴中央颞区棘波睡眠中癫痫性电持续状态
levetiracetamoxcarbazepinesodium valproatebenign epilepsy with central temporal spineselectrical status epilepticus of sleep
《中国合理用药探索》 2024 (004)
69-75 / 7
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