某院2021-2022年儿科门诊超说明书用药调查分析OACSTPCD

Objective:To investigate the status of off-label drug use in pediatric outpatient of Huizhou First Maternal and Child Health Care Hospital,and to analyze the countermeasures.Methods:Outpatient prescriptions in Huizhou First Maternal and Child Health Hospital from Oct.2021 to Sept.2022 were randomly selected,and off-label drug use was determined according to drug instructions.The incidence of off-label drug use,types of off-label drug use,children of different ages and drug categories of off-label drug use were summarized and analyzed.Results:A total of l,556 prescriptions were drawn,including 4,154 medication orders,and according to the number of prescriptions and medication orders,the incidence of off-label drug use was 36.70％(571/1,556)and 43.98％(1,827/4,154),respectively.The types of off-label drug use were mainly off-label indication(27.09％),off-label dosage(22.06％)and off-label frequency of administration(19.27％).The incidence of off-label drug use in infants and young children(from 29 d to 3 years old)was higher(＞40％).Drugs with the highest incidence of off-label drug use were endocrine regulator(59.86％),respiratory medicines(56.79％)and Chinese patent medicines(53.95％).Conclusion:Off-label drug use in pediatric outpatient is relatively common.Special attention should be paid to the use of medicines for infants and young children.Clinicians are supposed to issue prescriptions in strict accordance with the drug instructions,and the state should formulate relevant policies to regulate the behavior of off-label drug use in order to guarantee the medication safety for children.