屋尘螨皮下特异性免疫治疗支气管哮喘和(或)变应性鼻炎患儿全身不良反应的危险因素OACSTPCD

Objective:To probe into the risk factors for systemic reactions in children with bronchial asthma and(or)atopic rhinitis treated with subcutaneous immunotherapy for house dust mite.Methods:A total of 110 children diagnosed with asthma and(or)allergic rhinitis and treated with subcutaneous immunotherapy for house dust mite in Hangzhou Children's Hospital from Jan.2020 to Mar.2022 were retrospectively analyzed.History of adverse drug reactions after subcutaneous immunotherapy was recorded and risk factors were analyzed.Results:Systemic reactions were observed in 15 of the enrolled children.The total number of injections was 2,250,with a total of 43 systemic reactions(1.91％).Among 43 cases of systemic adverse reactions,79.07％(34/43)was grade Ⅰ and 16.28％(7/43)was grade Ⅱ.A total of 43 sub-systemic reactions occurred in 15 children,97.67％of which occurred within 30 minutes of injection,69.77％in the dose-increasing phase,and 95.35％in the high-concentration allergen vaccine,and the systemic reactions in the injection phase were mainly characterized by respiratory symptoms.The incidence of systemic reactions in the asthma group was higher than that in the non-asthma group,the allergen detection in hypersensitive group was higher than that in non-hypersensitive group,the No.4 bottle injection group was higher than the No.1,No.2 and No.3 bottle injection group,and the group with local adverse drug reactions during injection was higher than that without local adverse drug reactions,the differences were statistically significant(P＜0.05).Conclusion:Systemic reactions are more likely to occur in children with asthma,high sensitivity,previous local adverse drug reactions and No.4 bottle injection.In addition,recent infection,drug interruption,prolonged injection time,special events(violent exercise and hunger)before and after injection,and new allergic symptoms may be related to systemic reactions.