河南中医2024，Vol.44Issue(5)：784-789,6.DOI:10.16367/j.issn.1003-5028.2024.05.0145
基于NF-κB信号通路探讨乌梅丸联合消痔灵治疗慢性放射性直肠炎作用机制
Study on the Mechanism of Action of Mume Pill Combined with Xiaozhiling in the Treatment of Chronic Radiation Proctitis Based on NF-κB Signaling Pathway
摘要
Abstract
Mume Pill in the treatment of chronic radiation proctitis may inhibit the upstream regulatory point of nuclear factor kappa-B(NF-κB)signaling pathway transduction,down-regulate the phosphorylation of IκB protein,and then inhibit the activation of NF-κB.It can also down-regulate the expression of NF-κB in colon of immune colitis,inhibit the production of interleukin(IL)-1β,and reduce inflammatory response.Xiaozhiling(消痔灵,XZL)for enema in the treatment of radiation proctitis can effectively reduce the level of inflammatory factors and improve clinical efficacy.Mume Pill combined with XZL has a certain effect on chronic radiation proctitis by inhibiting intestinal inflammatory response through NF-κB.However,at present,there are few studies on chronic radiation proctitis at home and abroad,the molecular structure is not clear,and the diagnosis and treatment lack unity.Moreover,Mume Pill has many compo-nents,and each drug has a variety of pharmacological effects,and the research mechanism is complex.In the future,animal experiments and evidence-based medicine research are needed to further verify the mechanism of action of XZL combined with Mume Pill in the treatment of chronic radiation proctitis.关键词
乌梅丸/消痔灵/慢性放射性肠炎/NF-κB信号通路/《伤寒论》/张仲景Key words
Mume Pill/Xiaozhiling(消痔灵,XZL)/chronic radiation enteritis/NF-κB signaling pathway/Treatise on Cold Damage Dis-eases/Zhang Zhongjing分类
医药卫生引用本文复制引用
马玉婷,杜燕红,杨德群..基于NF-κB信号通路探讨乌梅丸联合消痔灵治疗慢性放射性直肠炎作用机制[J].河南中医,2024,44(5):784-789,6.基金项目
湖北省中医药管理局2023-2024年度中医药指导性项目(ZY2023F001) （ZY2023F001）
