基于NF-κB信号通路探讨乌梅丸联合消痔灵治疗慢性放射性直肠炎作用机制OA

Mume Pill in the treatment of chronic radiation proctitis may inhibit the upstream regulatory point of nuclear factor kappa-B(NF-κB)signaling pathway transduction,down-regulate the phosphorylation of IκB protein,and then inhibit the activation of NF-κB.It can also down-regulate the expression of NF-κB in colon of immune colitis,inhibit the production of interleukin(IL)-1β,and reduce inflammatory response.Xiaozhiling(消痔灵,XZL)for enema in the treatment of radiation proctitis can effectively reduce the level of inflammatory factors and improve clinical efficacy.Mume Pill combined with XZL has a certain effect on chronic radiation proctitis by inhibiting intestinal inflammatory response through NF-κB.However,at present,there are few studies on chronic radiation proctitis at home and abroad,the molecular structure is not clear,and the diagnosis and treatment lack unity.Moreover,Mume Pill has many compo-nents,and each drug has a variety of pharmacological effects,and the research mechanism is complex.In the future,animal experiments and evidence-based medicine research are needed to further verify the mechanism of action of XZL combined with Mume Pill in the treatment of chronic radiation proctitis.