水环境中新污染物的分离富集与测定——以磺胺类合成药物为例OA北大核心CSTPCD

As a new class of emerging contaminants,sulfonamides(SAs)represent the earliest class of synthetic antimicro-bial drugs to be applied and widely used in humans,agriculture,animal husbandry,and aquaculture.SA synthetic drugs that enter the body are metabolically discharged into the aquatic environment,posing potential threats to aquatic ecosystems and human health.Therefore,accurate analysis and determination of SA synthetic drugs in the environment are the basis for exploring their environmental biogeochemical characteristics.In recent years,with the progress of science and technology,methods for rapid and sensitive determination of trace SA synthetic drugs in the aquatic environment have been developed,especially the sample pretreatment and separation and preconcentration technology have made a leap.Herein,the research progress of sample pretreatment technology and analysis methods for SA synthetic drugs in the aquatic environment in re-cent years was summarized,advantages and disadvantages of different environmental sample pretreatment technologies and analysis methods were analyzed,and based on this,development direction of the analysis and determination of SA synthetic drugs in the aquatic environment was prospectively investigated.Solid-phase extraction(SPE),an alternative to liq-uid-liquid extraction,with the advantages of high recovery rate,strong selectivity,good reproducibility,low cost,environ-mental friendliness,and automation has been widely used for the separation and enrichment of trace SA synthetic drugs in the aquatic environment.Moreover,with the development of new adsorbent materials,the sensitivity and selectivity of SPE have been considerably improved.Presently,liquid chromatography(LC)combined with tandem mass spectrometry(MS/MS)is the primary quantitative analysis method for detecting SA synthetic drugs.This method has the advantages of a low detection limit,high sensitivity,simultaneous detection of multiple target substances,and good reproducibility.In the future,more simple,rapid,and sensitive analytical methods should be developed by focusing on the residues of SA metabo-lites and degradation products in the aquatic environment.This will enable the monitoring of the ecological and environ-mental effects of synthetic drugs in the aquatic environment more effectively.