间充质干细胞来源外泌体在多囊卵巢综合征发生和发展中的研究进展OACSTPCD
Research progress of exosomes derived from mesenchymal stem cells on the pathogenesis and progression of PCOS
多囊卵巢综合征(PCOS)是一种代谢性疾病和常见的内分泌疾病,其患病率在10％～20％之间.慢性低度炎症和颗粒细胞不规则凋亡在PCOS不孕症的发病机制中起着至关重要的作用.间充质干细胞(MSCs)衍生的外泌体是脂质双分子层复合物,可以作为蛋白质、脂质、DNA和不同类型RNA在细胞间转移的介质,大小在30～150 nm,对PCOS具有调节免疫应答、抗炎和抑制颗粒细胞凋亡等作用.尽管许多研究证明外泌体对PCOS的发生和发展有影响,但其确切的作用机制尚不清楚.本文综述了 MSCs来源的外泌体在PCOS治疗中的潜在作用,以期为后续研究无细胞治疗PCOS提供理论依据.
PCOS is a multifactorial metabolic and most common endocrine disorder and its prevalence varies from 10％ to 20％.Chronic low-grade inflammation and irregular apoptosis of granulosa cells play a crucial role in the pathogenesis of PCOS associated infertility.Mesenchymal stem cells(MSCs)-derived exosomes are lipid bilayer complexes that act as a means of intercellular transferring of proteins,lipids,DNA and different types of RNAs,ranging from 30 to 150 nm in size.And they have some effects on PCOS,such as regulating immunity response,anti-inflammatory and suppress apoptosis of granulosa cells.Although there are many studies demonstrating the effects of exosomes on the pathogenesis and progression of PCOS,their exact mechanisms are still unknown.In the present study,we will review the potential effects of MSC-derived exosomes on the treatment of PCOS in order to provide theoretical basis for subsequent research on cell-free therapy for PCOS.
杨丽;王月莺
济宁市第一人民医院生殖医学中心,济宁 272002||济宁市妊娠障碍性疾病研究重点实验室,济宁 272002武汉大学中南医院生殖医学中心,武汉 430070||济宁市妊娠障碍性疾病研究重点实验室,济宁 272002
临床医学
间充质干细胞外泌体多囊卵巢综合征
Mesenchymal stem cellsExosomePCOS
《生殖医学杂志》 2024 (005)
682-686 / 5
国家自然科学基金(82101756);济宁市重点研发计划(2021YXNS046)
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