生殖医学杂志2024，Vol.33Issue(5)：682-686,5.DOI:10.3969/j.issn.1004-3845.2024.05.020
间充质干细胞来源外泌体在多囊卵巢综合征发生和发展中的研究进展
Research progress of exosomes derived from mesenchymal stem cells on the pathogenesis and progression of PCOS
摘要
Abstract
PCOS is a multifactorial metabolic and most common endocrine disorder and its prevalence varies from 10％ to 20％.Chronic low-grade inflammation and irregular apoptosis of granulosa cells play a crucial role in the pathogenesis of PCOS associated infertility.Mesenchymal stem cells(MSCs)-derived exosomes are lipid bilayer complexes that act as a means of intercellular transferring of proteins,lipids,DNA and different types of RNAs,ranging from 30 to 150 nm in size.And they have some effects on PCOS,such as regulating immunity response,anti-inflammatory and suppress apoptosis of granulosa cells.Although there are many studies demonstrating the effects of exosomes on the pathogenesis and progression of PCOS,their exact mechanisms are still unknown.In the present study,we will review the potential effects of MSC-derived exosomes on the treatment of PCOS in order to provide theoretical basis for subsequent research on cell-free therapy for PCOS.关键词
间充质干细胞/外泌体/多囊卵巢综合征Key words
Mesenchymal stem cells/Exosome/PCOS分类
医药卫生引用本文复制引用
杨丽,王月莺..间充质干细胞来源外泌体在多囊卵巢综合征发生和发展中的研究进展[J].生殖医学杂志,2024,33(5):682-686,5.基金项目
国家自然科学基金(82101756) （82101756）
济宁市重点研发计划(2021YXNS046) （2021YXNS046）
