生殖医学杂志2024，Vol.33Issue(5)：592-598,7.DOI:10.3969/j.issn.1004-3845.2024.05.005
胚胎冷冻保存时间对首次冻融胚胎移植临床结局和出生子代的影响
Effects of storage time on clinical pregnancy and neonatal outcomes of the first frozen embryo transfer
摘要
Abstract
Objective:To explore the effects of embryo storage time after vitrification on clinical pregnancy and neonatal outcomes for the first frozen embryo transfer cycle. Methods:A retrospective cohort study was conducted on 4 075 women who underwent the first frozen embryo transfer after fresh embryo transfer in Assisted Reproductive Center of Jiangxi Maternal and Child Health Hospital from January 2014 to June 2022.According to the storage time,the patients were divided into four groups:group A(≤3 months,n=993),group B(4 to 6 months,n=1 757),group C(7 to 12 months,n=880),and group D(13 to 24 months,n=445).Baseline characteristics,the embryo transfer,clinical pregnancy and neonatal outcomes among four groups were compared,and multiple logistic regression model was used to analyze the impact of embryo storage time on pregnancy and neonatal outcomes. Results:There were significant differences in embryo cryopreservation time,age at the time of egg retrieval,body mass index(BMI),and the proportion of primary infertility among the four groups(P＜0.05).There were significant differences in the number of retrieved eggs,available embryos,the year of embryo freezing,endometrial preparation scheme,and single embryo transfer rate among the four groups(P＜0.01),while there was no significant difference in the blastocyst transfer rate among the four groups(P＞0.05).There were no significant differences in clinical pregnancy rate,multiple pregnancy rate,and the miscarriage rate among the four groups after FET(P＞0.05).The live birth rates of group A,B,C and D after first frozen embryo transfer were 50.86％,53.27％,49.55％ and 51.01％,respectively,showing no significant differences among the four groups(P＞0.05).As for all singletons born after frozen embryo transfer,no significant differences in preterm birth,very preterm birth,low birth weight,very low birth weight,fetal macrosomia,sex ratio and birth defects were observed among the four groups(P＞0.05).The results of multiple logistic regression showed that embryo storage time had no significant effects on live birth rate,β-HCG positive rate,clinical pregnancy rate,the implantation rate and the miscarriage rate. Conclusions:The storage time within 2 years does not affect the live birth rate after the first frozen embryo transfer,nor does it increase the risk of preterm birth,low birth weight and birth defects.关键词
保存时间/妊娠结局/出生子代/冻融胚胎移植Key words
Storage time/Pregnancy outcome/Offspring/Frozen embryo transfer分类
医药卫生引用本文复制引用
吴兴武,夏雷震,黄志辉,辛才林,田莉峰,伍琼芳..胚胎冷冻保存时间对首次冻融胚胎移植临床结局和出生子代的影响[J].生殖医学杂志,2024,33(5):592-598,7.基金项目
江西省卫生健康委科技计划(20195490) （20195490）
江西省中医药管理局科技计划(2022A256) （2022A256）
