中国肺癌杂志2024，Vol.27Issue(4)：276-282,7.DOI:10.3779/j.issn.1009-3419.2024.106.07
肺癌类器官在肺癌精准医学的应用及其研究进展
Application and Research Progress of Lung Cancer Organoid in Precision Medicine for Lung Cancer
摘要
Abstract
The continuous advancement of molecular detection technology has greatly propelled the develop-ment of precision medicine for lung cancer.However,tumor heterogeneity is closely associated with tumor metastasis,recurrence,and drug resistance.Additionally,different lung cancer patients with the same genetic mutation may exhibit varying treatment responses to different therapeutic strategies.Therefore,the development of modern precision medicine urgently requires the precise formulation of personalized treatment strategies through personalized tumor models.Lung cancer organoid(LCO)can highly simulate the biological characteristics of tumor in vivo,facilitating the application of innovative drugs such as antibody-drug conjugate in precision medicine for lung cancer.With the development of co-culture model of LCO with tumor microenvironment and tissue engineering technology such as microfluidic chip,LCO can better preserve the biological characteristics and functions of tumor tissue,further improving high-throughput and automated drug sensitivity experiment.In this review,we combine the latest research progress to summarize the applica-tion progress and challenges of LCO in precision medicine for lung cancer.关键词
肺肿瘤/类器官/精准医学Key words
Lung neoplasms/Organoid/Precision medicine引用本文复制引用
黄志诚,李博文,王亚东,薛剑超,魏泽文,梁乃新,李单青..肺癌类器官在肺癌精准医学的应用及其研究进展[J].中国肺癌杂志,2024,27(4):276-282,7.基金项目
This paper was supported by the grant from National High Level Hospital Clinical Research Project Funding of Peking Union Medical College Hospital(No.2022-PUMCH-B-011)(to Shanqing LI). 本文受北京协和医院中央高水平医院临床科研专项(No.2022-PUMCH-B-011)资助 （No.2022-PUMCH-B-011）
