微移植治疗急性髓系白血病免疫机制OA北大核心CSTPCD
Immune mechanisms of microtransplantation in the treatment of acute myeloid leukemia
近年来,微移植(microtransplantation,MST)治疗急性髓系白血病(acute myeloid leukemia,AML)等血液肿瘤引起广泛关注和应用.该技术不仅有效提高了 AML患者的生存率,还具有移植物抗白血病效应(graft-versus-leukemia effect,GVL)轻微、临床显示出高效微毒的优点,是一种在保存受者正常免疫功能的条件下进行造血干细胞移植的治疗模式.但MST有效的具体机制尚不十分清楚,文章对MST治疗AML的可能免疫机制进行综述,为MST技术的优化和推广应用提供依据.
In recent years,MST has attracted widespread attention and application in the treatment of hematological malignancies such as acute myeloid leukemia(AML).This technique not only effectively improves the survival rate of AML patients but also possesses the advantages of mild graft-versus-leukemia effect(GVHD),high efficiency,and low toxicity.It represents a therapeutic modality of hematopoietic stem cell transplantation that preserves the recipient's normal immune function.However,the specific mechanisms underlying the effectiveness of MST are not yet fully understood.This article reviews the possible immune mechanisms of MST in treating AML,providing a basis for the optimization and widespread application of MST technology.
郑涵雪;李莉娟;张连生
兰州大学第二临床医学院,甘肃兰州 730000兰州大学第二医院,甘肃兰州 730000
临床医学
微移植急性髓系白血病免疫机制
microtransplantationacute myeloid leukemiaimmune mechanisms
《中国实用内科杂志》 2024 (004)
275-279 / 5
国家自然科学基金(82360029);国家血液系统疾病临床医学研究中心委托课题(2021WWA01);甘肃省科技计划项目临床医学研究中心建设(21JR7RA435);甘肃省科技计划项目自然科学基金(21JR7RA394);甘肃省科技计划项目自然科学基金(21JR11RA104)
评论