Vascular endothelial growth factor:a double-edged sword in the development of white matter lesionsOA
As the population ages,the burden of age-related diseases becomes greater.Currently,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common form.However,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of cSVD.The term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).
Narek Manukjan;Daniel Fulton;Zubair Ahmed;WMatthijs Blankesteijn;Sébastien Foulquier;
Department of Pharmacology and Toxicology,Maastricht University,Maastricht,The Netherlands CARIM-School for Cardiovascular Diseases,Maastricht University,Maastricht,The Netherlands Neuroscience and Ophthalmology,Institute of Inflammation and Ageing,University of Birmingham,Edgbaston,Birmingham,UKNeuroscience and Ophthalmology,Institute of Inflammation and Ageing,University of Birmingham,Edgbaston,Birmingham,UK Centre for Trauma Sciences Research,University of Birmingham,Edgbaston,Birmingham,UKDepartment of Pharmacology and Toxicology,Maastricht University,Maastricht,The Netherlands CARIM-School for Cardiovascular Diseases,Maastricht University,Maastricht,The NetherlandsDepartment of Pharmacology and Toxicology,Maastricht University,Maastricht,The Netherlands CARIM-School for Cardiovascular Diseases,Maastricht University,Maastricht,The Netherlands MHeNs-School for Mental Health and Neuroscience,Maastricht University,Maastricht,The Netherlands Department of Neurology,Maastricht University Medical Center,Maastricht,The Netherlands
临床医学
pathologybecomingwhite
《Neural Regeneration Research》 2025 (001)
P.191-192 / 2
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