中风与神经疾病杂志2024，Vol.41Issue(5)：402-407,6.DOI:10.19845/j.cnki.zfysjjbzz.2024.0078
中国人群帕金森病轻度认知障碍综合认知域评估量表的筛选及诊断效度分析
Screening and diagnostic validity of the comprehensive cognitive domain assessment scale for mild cognitive impair-ment in the Chinese population with Parkinson disease
摘要
Abstract
Objective To develop an appropriate comprehensive scale for mild cognitive impairment in Parkinson dis-ease(PD-MCI)due to various diagnostic methods for PD-MCI and a lack of consensus on the applicable neuropsychological scales for PD-MCI.Methods A total of 92 non-dementia PD patients with a confirmed diagnosis were enrolled in this study,and all patients were assessed using the comprehensive scale of five cognitive domains recommended by the Chinese version of PD-MCI guidelines and Movement Disorder Society(MDS).Based on the norms of healthy controls assessed by the same scale,the patients were divided into non-cognitive impairment PD group and PD-MCI group.The t-test was used to observe the consistency between groups;the receiver operating characteristic(ROC)curve was used to investigate the cut-off value of each scale with the highest sensitivity and specificity in identifying the impairment in each cognitive domain of PD-MCI;a binary lo-gistic regression analysis was used to determine the specific contents of the comprehensive cognitive domain assessment scale for PD-MCI.Results This study showed that the ten-point comprehensive cognitive domain assessment scale based on long-time memory in Brief Visuospatial Memory Test,Clock Drawing Test,digit span backward test,Trail Making Test A,Verbal Flu-ency Test,Trail Making Test B,Similarities,Boston Naming Test,long-time recall memory in Auditory Verbal Learning Test,and short-time recall memory in Wechsler Memory Scale-IV Logical Memory Test had a significant diagnostic validity in predict-ing PD-MCI,with an area under the ROC curve of 0.971(95%CI 0.941‒1.000).Conclusion The recommended cut-off value can be used to perform a subtype analysis of PD-MCI and observe the outcome and clinical specificity of different subtypes of PD-MCI,and therefore,it has a certain clinical significance.关键词
帕金森病/轻度认知障碍/神经心理量表Key words
Parkinson disease/Mild cognitive impairment/Neuropsychological scale分类
医药卫生引用本文复制引用
薛晓帆,许二赫,吴志悦,黄安琪,安静,刘国臻,张丽娟,许保磊,冯焕焕,陈彪..中国人群帕金森病轻度认知障碍综合认知域评估量表的筛选及诊断效度分析[J].中风与神经疾病杂志,2024,41(5):402-407,6.基金项目
国家重点研发计划(2021YFC2501200) （2021YFC2501200）
