中医药调控痛风性肾病尿酸转运蛋白的肾保护机制研究OA

Gouty nephropathy is one of the common complications of gout and hyperuricemia,which can eventually progress to kidney failure and threaten life.High blood uric acid level is the basis of gouty nephropathy.In the physiological process of uric acid metabolism,uric acid transporters(GLUT9,URAT1,OAT4,OAT10,GLUT12,NPT1,NPT4,OAT1,OAT2,OAT3,etc.)play an important role in promoting uric acid excretion,and are also some key targets of uric-lowering drugs.The authors reviewed and collated the relevant literature on the treatment of gouty nephropathy by traditional Chinese medicine(TCM)in recent 3 years.It was found that some effective components of Chinese herbal medicinals and Chinese herbal medicinal formulae have their unique advantages in reducing blood uric acid level by regulating uric acid transporters.The former includes water extract of Herb of Spicate Clerodendranthus,cichory acid,total saponins of Achyranthus rhizome,luteolin,Lycium barbarum polysaccharide,total glycosides of Paeoniflorin,Poria extract and andrographis extract;while the latter includes Lingze mixture,Tongfeng Ning,Jianpi Qingre Lizhuo decoction,compound Qiling Formula granules,and Paisuan Hushen decoction.Many TCM monomers and compounds can significantly regulate GLUT9,OAT1,OAT3,URAT1,ABCG2 transporters,reduce blood uric acid level,improve renal tissue inflammation and injury caused by high blood uric acid,and protect kidneys.