中医药临床杂志2024，Vol.36Issue(5)：817-822,6.DOI:10.16448/j.cjtcm.2024.0503
基于内质网应激反应探究针刺治疗卒中后抑郁的机制
Based on Endoplasmic Reticulum Stress Response to Discusses the Mechanism of Acupuncture Treatment for Post-stroke Depression
摘要
Abstract
Post-stroke depression(PSD)occurs after stroke,with symptoms such as depression,loss of interest,decreased self-worth,and sleep disturbance as its main clinical manifestations.In order to explore the specific mo-lecular mechanism of acupuncture treatment of PSD,the author reviewed the information and literature in domestic and foreign databases such as PubMed,CNKI,Wanfang,and VIP in recent years,and compared the relationship between PSD and endoplasmic reticulum stress(ERS).This paper summarizes and analyzes the clinical research and animal ex-perimental studies on the relationship between acupuncture and ERS to treat PSD,and clarifies the mechanism of ERS and the possible targets of acupuncture to intervene in ERS.This article concluded that acupuncture may improve the clinical symptoms of PSD patients by regulating ERS-related pathway proteins,inhibiting inflammatory responses and overloading ERS-mediated apoptosis.Therefore,this study summarizes the relevant target mechanisms of ERS after acupuncture treatment regulates PSD,with a view to providing new ideas and certain scientific basis for the explorable target directions of acupuncture treatment of PSD in the future.关键词
卒中后抑郁/内质网应激反应/针刺/眼针/未折叠蛋白反应/作用机制/异病同治Key words
Post-Stroke depression/Endoplasmic reticulum stress response/Acupuncture/Eye acupuncture/Un-folded protein response/Mechanism of action/Same treatment for different diseases分类
医药卫生引用本文复制引用
杨明岳,海英..基于内质网应激反应探究针刺治疗卒中后抑郁的机制[J].中医药临床杂志,2024,36(5):817-822,6.基金项目
辽宁省"兴辽英才计划"项目(XLYC2002104) （XLYC2002104）
广东省新黄埔中医药联合创新项目(2022IR002) （2022IR002）
