分析化学2024，Vol.52Issue(5)：597-608,12.DOI:10.19756/j.issn.0253-3820.231263
脂滴荧光探针的研究进展
Recent Progress on Lipid Droplets-Targetable Fluorescent Probes
摘要
Abstract
Lipid droplets(LDs)are important organelles in eukaryotic cells and play a significant role in life activities such as lipid metabolism.Detection of LDs not only contributes to understanding the molecular mechanisms that lipid droplets participate in life activities,but also has important guidance for the diagnosis and treatment of diseases.LDs fluorescent probes can be divided into two categories,including(1)monofunctional LDs locating probes,and(2)multifunctional single-molecule LDs fluorescent probes with multiple functions such as locating LDs,monitoring microenvironment,imaging dual organelles simultaneously,detecting active species in LDs and performing photodynamic therapy.This paper summarized and reviewed the LD-specific fluorescent probes reported in recent years,and discussed the development trend of LDs fluorescent probes applied to explore the molecular mechanism of interaction between important cellular physiological processes and other organelles,and the diagnosis of related diseases.关键词
脂滴/荧光探针/生物成像/细胞器靶向/评述Key words
Lipid droplets/Fluorescent probe/Bioimaging/Organelle targeting/Review引用本文复制引用
王丹,刘越,张跃伟,樊丽,于雪..脂滴荧光探针的研究进展[J].分析化学,2024,52(5):597-608,12.基金项目
吉林省科技发展计划项目(Nos.YDZJ202301ZYTS312,YDZJ202201ZYTS618)、吉林省教育厅科学技术研究项目一般项目(No.JJKH20240301KJ)、国家自然科学基金项目(No.81901814)和吉林市科技局杰出青年人才培养专项项目(No.20230103015)资助. Supported by the Program of Science and Technology Development Plan of Jilin Province(Nos.YDZJ202301ZYTS312,YDZJ202201ZYTS618),the General Project of Jilin Provincial Department of Education Science and Technology Research Project(No.JJKH20240301KJ),the National Natural Science Foundation of China(No.81901814)and the Outstanding Youth Training Program of Jilin City(No.20230103015). （Nos.YDZJ202301ZYTS312,YDZJ202201ZYTS618）
