吉林中医药2024，Vol.44Issue(5)：582-589,8.DOI:10.13463/j.cnki.jlzyy.2024.05.021
六君子汤中理气药陈皮挥发性成分与胃肠动力调节关联性研究
Study on the correlation between dried tangerine peel volatile components in Liujunzi decoction and regulation of gastrointestinal motility
摘要
Abstract
Objective From the perspective of regulating gastric motility,to analyze the qi-regulating effect of volatile components in dried tangerine peel,a qi-regulating drug,in the qi-tonifying formula Liujunzi decoction,to compare the effects of different-aged dried tangerine peel volatile components on gastric emptying and small intestine propulsion in rats with spleen deficiency,and then to explore the association between dried tangerine peel volatile oil and gastrointestinal motility regulation in rats with spleen deficiency.Methods The finger prints of volatile oil in 15 batches of dried tangerine peel from different origins and years were established by GC.The effect of volatile components in dried tangerine peel on improving gastrointestinal motility was evaluated by using gastric emptying and small intestine propulsion as indicators.Finally,partial least square regression analysis and gray scale analysis were used to analyze the correlation between their finger prints and the regulation of gastrointestinal motility in rats with spleen deficiency.Results The volatile components of 15 batches of dried tangerine peel could promote gastric emptying and small intestine propulsion,and their gain intensity in Liujunzi decoction was best for those with 5 or 10 years.In the GC chromatograms of volatile components of 15 batches of different-aging years,the myrcene(peak 3),D-limonene(peak 4),and peak 9 were the potential medicinal components that improved gastrointestinal motility.Conclusion Volatile oil in the qi-regulating dried tangerine peel volatile components in Liujunzi decoction have the synergistic effect of regulating and replenishing qi through the regulation of gastric motility in rats with spleen deficiency,which is the result of multiple active components.This study preliminarily reveals the relationship between the qi-regulating effect of volatile components in dried tangerine peel in Liujunzi decoction and the stomach motility regulation in rats with spleen deficiency,providing a new idea for exploring the material basis of qi-regulating effect of dried tangerine peel in Liujunzi decoction.关键词
六君子汤/陈皮挥发油/指纹图谱/胃肠动力/谱效关系Key words
Liujunzi decoction/dried tangerine peel volatile oil/finger print/gastrointestinal motility/spectrum effect relationship分类
医药卫生引用本文复制引用
吕邵娃,郭红丽,李影,孙爽..六君子汤中理气药陈皮挥发性成分与胃肠动力调节关联性研究[J].吉林中医药,2024,44(5):582-589,8.基金项目
黑龙江省博士后科研启动金项目(LBH-Q21189) （LBH-Q21189）
国家自然科学基金青年科学基金项目(81803985) （81803985）
黑龙江省"头雁"团队支持项目(黑龙江省头雁行动领导小组文件[2019]5号) （黑龙江省头雁行动领导小组文件[2019]5号）
