昆明医科大学学报2024，Vol.45Issue(5)：116-122,7.DOI:10.12259/j.issn.2095-610X.S20240518
T淋巴细胞亚群与急性髓系白血病病理特征的关系及预测化疗预后的价值分析
The Relationship between T Lymphocyte Subsets and Pathological Characteristics of Acute Myeloid Leukemia and the Value of Predicting Chemotherapy Prognosis
摘要
Abstract
Objective To analyze the relationship between the level of peripheral blood T lymphocyte subsets and the pathological characteristics of patients with acute myeloid leukemia(AML),as well as its prognostic value for chemotherapy.Methods A total of 80 patients with AML in Beijing Aerospace General Hospital from April 2017 to April 2022 were selected as the study group,and 80 healthy volunteers matched for gender and age were selected as the control group.The general data and peripheral blood T lymphocyte subsets levels(CD4+/CD8+,CD3+and CD4+)of the two groups were compared,and the peripheral blood T lymphocyte subsets levels of patients with different pathological characteristics in the study group before the chemotherapy were compared.The clinical data and peripheral blood T lymphocyte subsets of patients with the different prognosis were compared in the study group,and the influencing factors of poor prognosis of AML were analyzed,and the value of peripheral blood T lymphocyte subsets in predicting poor prognosis of AML was analyzed.Results Compared with the control group,the levels of peripheral blood CD4+/CD8+,CD3+and CD4+in the study group before the chemotherapy were significantly decreased(P<0.05);the levels of CD4+/CD8+,CD3+and CD4+in peripheral blood of patients with positive NPM1 mutation,positive FLT3-ITD mutation,and low-risk stratification were higher than those of patients with negative NPM1 mutation,negative FLT3-ITD mutation,and high-risk stratification,respectively(P<0.05);The age and high-risk stratification of the poor prognosis patients in the research group were higher than those of the good prognosis patients,and the levels of CD4+/CD8+,CD3+and CD4+in peripheral blood before chemotherapy were lower than those of the good prognosis patients(P<0.05);Age,risk stratification,CD4+/CD8+,the CD3+and CD4+levels in peripheral blood before the chemotherapy were all factors influencing poor prognosis in AML patients(P<0.05);The areas under the curve(AUC)of CD4+/CD8+,CD3+and CD4+in peripheral blood before the chemotherapy for predicting poor prognosis in AML were 0.702,0.738,and 0.759,respectively.Conclusion The decrease in CD4+/CD8+,CD3+and CD4+levels in peripheral blood of AML patients is associated with NPM1 mutation,FLT3-ITD mutation and risk stratification,and has certain predictive value in predicting poor prognosis of AML.关键词
急性髓系白血病/T淋巴细胞亚群/预后/预测Key words
Acute myeloid leukemia/T lymphocyte subsets/Prognosis/Forecast分类
医药卫生引用本文复制引用
刘春艳,常炳庆,李超,任欣,刘小琴..T淋巴细胞亚群与急性髓系白血病病理特征的关系及预测化疗预后的价值分析[J].昆明医科大学学报,2024,45(5):116-122,7.基金项目
北京航天总医院创新基金资助项目(2020-605) （2020-605）
