食品工业科技2024，Vol.45Issue(12)：151-159,9.DOI:10.13386/j.issn1002-0306.2023120301
富含γ-氨基丁酸的萌发红小豆对T2DM小鼠肠道菌群的影响
Effect of Rich GABA of Germinated Adzuki Bean on Intestinal Microflora in T2DM Mice
摘要
Abstract
In order to study the effects of GABA-rich germinated adzuki bean on blood glucose level and intestinal flora in T2DM mice.C57BL/6J mice were used as subjects to construct T2DM model by high fat diet+STZ injection.Different doses of GABA-rich germinated adzuki bean were used to treat T2DM mice for 6 weeks and 16S rRNA sequencing technique was used to identify the microbial structure and distribution in the cecal contents of T2DM mice.The results showed that different doses of GABA-rich adzuki bean dietary intervention could significantly reduce the FBG value of T2DM mice,and the FBG value of high dose GABA-rich adzuki bean(TF3)group was 8.36±0.78 mmol/L,which was 54.09％,lower than that of model group(M).In addition,TF3 diet induced significant changes in intestinal flora abundance in T2DM mice.Firmicutes abundance at gate level was 35.96％,which decreased by 53.17％compared with M model group,and Bacteroidetes and Verrucomicrobia abundance were significantly up-regulated.In summary,the improvement of glucose and lipid metabolism by TF3 diet was significantly correlated with the abundance of dominant bacteria in Bacteroidetes and Verrucomicrobia,suggesting that high dose of GABA-rich adzuki bean diet could alleviate hyperglycemia symptoms in T2DM mice through beneficial bacteria,which provided reference for further explaining the relationship between T2DM and intestinal flora.关键词
红小豆/萌发/γ-氨基丁酸/2型糖尿病/肠道菌群Key words
adzuki bean/germinating/GABA/T2DM/intestinal microflora分类
轻工纺织引用本文复制引用
姜秀杰,张家瑜,李莹,迟晓星,孙东波,曹冬梅,张东杰..富含γ-氨基丁酸的萌发红小豆对T2DM小鼠肠道菌群的影响[J].食品工业科技,2024,45(12):151-159,9.基金项目
黑龙江省博士后资助经费(LBH-Z23241) （LBH-Z23241）
黑龙江省"百千万"工程科技重大专项(2021ZX12B06) （2021ZX12B06）
黑龙江省自然科学基金项目(SS2022C001) （SS2022C001）
学成、引进人才科研启动计划项目(XYB202210) （XYB202210）
黑龙江省杂粮生产与加工优势特色学科项目(2022-78) （2022-78）
黑龙江八一农垦大学"三纵"基础培育项目(ZRCPY202122). （ZRCPY202122）
