食品工业科技2024，Vol.45Issue(12)：327-333,7.DOI:10.13386/j.issn1002-0306.2023070036
黄芩提取物抗UVA诱导NIH3T3细胞光老化的作用
Scutellaria baicalensis Extract Inhibits the UVA-induced Photoaging in NIH3T3 Cells
摘要
Abstract
Objective:To investigate the protective effect of Scutellaria baicalensis extract on ultraviolet(UVA)-induced photoaging in a fibroblast cell line(NIH3T3).Methods:The cellular photoaging model was established by UVA irradiation,and the protective effects of Scutellaria baicalensis extract on photoaging fibroblasts were investigated using CCK-8 assay,β-galactosidase staining,DAPI staining,and immunofluorescence staining.Results:Scutellaria baicalensis extract significantly promoted cell proliferation and migration of NIH3T3 cells(P＜0.05),increased the cell viability of NIH3T3 cells after UVA irradiation,reduced UVA-induced cell apoptosis,and the expression of senescence-associated marker β-galactosidase(SA-β-gal).It also promoted the regeneration of endogenous type Ⅰ and type Ⅳ collagen,reversing collagen loss induced by UVA irradiation,collectively contributing to the defense against cellular photoaging.Conclusion:Scutellaria baicalensis extract effectively inhibits the photoaging of NIH3T3 cells induced by UVA irradiation.关键词
黄芩提取物/抗衰老/光老化/植物提取物Key words
Scutellaria baicalensis/anti-aging/photoaging/plant extract分类
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蔡春梅,黄玉叶,李丽燕,余悦,刘小娟,肖树雄,卢丽..黄芩提取物抗UVA诱导NIH3T3细胞光老化的作用[J].食品工业科技,2024,45(12):327-333,7.基金项目
化妆品植物原料安全性评价研究(广东省药品监督管理局科技创新项目2022ZDZ04) （广东省药品监督管理局科技创新项目2022ZDZ04）
广东省医学科学技术研究基金面上项目(B2021160). （B2021160）
