褐藻胶寡糖的酶法定向制备及其结构-功能关系的研究进展OA北大核心CSTPCD
Research Progress on the Directed Enzymatic Preparation and Structure-Function Relationship of Alginate Oligosaccharides
褐藻胶寡糖(alginate oligosaccharides,AOS)是由褐藻胶降解得到的含有2～10个单糖的线性低分子质量聚合物,具有多种生物活性,包括抗炎、抗菌、抗氧化、抗肿瘤、免疫调节等,在医药、食品、饲料和农业等领域有广泛的应用.AOS的生物活性与其结构密切相关,包括降解方式、聚合度、甘露糖醛酸与古罗糖醛酸比值、非还原端结构、分子修饰等.酶法降解褐藻胶可定向制备具有特定单体组成和聚合度的功能性AOS,且产物分布与酶的来源、性质、反应条件等有关.本文系统综述了酶法制备AOS的方法及影响因素,并讨论了褐藻胶寡糖结构-功能的关系,以期为AOS的定向制备和应用提供理论参考.
Alginate oligosaccharides(AOS)are low molecular mass linear polymers containing 2-10 monosaccharides obtained by the degradation of alginate.They have various bioactivities including anti-inflammatory,antibacterial,antioxidant,antitumor,and immunomodulation.Thus,AOS have a wide range of applications in the fields of medicine,food,feed and agriculture.The bioactivity of AOS is closely related to its structure,including mode of degradation,degree of polymerization,ratio of mannuronic acid to guluronic acid,non-reducing end structure,and modification.Directed enzymatic degradation of alginate produces functional AOS with specific monomer composition and polymerization degree.Furthermore,the sources,properties and reaction conditions of enzymes affect the product distribution.In this article,the enzymatic preparation of functional AOS and its influential factors are systematically reviewed,and the structure-function relationship of functional AOS is discussed.It is expected that this review will provide a theoretical reference for the directed preparation and application of AOS.
崔永燕;杨敏;刘楠;王珊珊;孙永;孙国辉;周德庆
中国水产科学研究院黄海水产研究所,山东青岛 266071||上海海洋大学食品学院,上海 201306中国水产科学研究院黄海水产研究所,山东青岛 266071||中国海洋大学食品科学与工程学院,山东青岛 266003中国水产科学研究院黄海水产研究所,山东青岛 266071
轻工业
褐藻胶褐藻胶寡糖酶法定向制备生物活性结构
alginatealginate oligosaccharidesdirected enzymatic preparationbioactivitystructure
《食品科学》 2024 (010)
320-329 / 10
国家自然科学基金青年科学基金项目(42106110);中国水产科学研究院基本科研业务费资助项目(2023TD72)
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