天津中医药大学学报2024，Vol.43Issue(5)：450-456,7.DOI:10.11656/j.issn.1673-9043.2024.05.11
中药复方对特发性肺纤维化干预机制的实验研究进展
Experimental research progress of traditional Chinese medicine compound on the intervention mechanism of idiopathic pulmonary fibrosis
摘要
Abstract
Idiopathic pulmonary fibrosis(IPF)is a disease characterized by diffuse alveolitis and structural disturbances in the alveoli,eventually leading to interstitial fibrosis of the lungs.Clinically,nintedanib or pirfenidone is often used for treatment,but it is prone to drug resistance and has many adverse reactions.In this paper,by reviewing the relevant literature on the intervention mechanism of traditional Chinese medicine(TCM)compound for idiopathic pulmonary fibrosis in recent years,we found that Buyang Huanwu Decoction,Shizao Decoction,Bufei Decoction,Maimendong Decoction,Xuefu Zhuyu Decoction and Yangfei Huoxue Decoction have certain intervention effects on IPF,which mechanism of action is mainly related to the regulation of TGF-β1/Smad,PI3K-Akt,NF-κB and other signaling pathways,anti-inflammatory and regulation of oxidative stress.In this paper,we summarized the experimental research on the intervention mechanism of IPF by TCM compound in the past five years,and summarized the high frequency of medicinal odors and their efficacy classification,so as to provide reference for further exploring the mechanism of TCM against IPF.关键词
特发性肺纤维化/发病机制/中药复方/干预机制Key words
idiopathic pulmonary fibrosis/pathogenesis/traditional Chinese medicine compound/intervention mechanisms分类
医药卫生引用本文复制引用
何家琛,李佳玮,刘志东..中药复方对特发性肺纤维化干预机制的实验研究进展[J].天津中医药大学学报,2024,43(5):450-456,7.基金项目
中央引导地方科技发展专项(21ZYJDJC00020) （21ZYJDJC00020）
现代中医药海河实验室科技项目(22HHZYSS00005) （22HHZYSS00005）
国家中医药管理局青年岐黄学者项目. （）
