云南化工2024，Vol.51Issue(5)：35-38,4.DOI:10.3969/j.issn.1004-275X.2024.05.09
草乌甲素杂质——滇乌碱的制备与应用
Preparation and Application of Yunaconitine an Impurity of Bulleyaconitine A
付彬彬 1龚爽 1龚云麒 1刘军锋1
作者信息
- 1. 昆药集团股份有限公司,云南 昆明 650021
- 折叠
摘要
Abstract
(Objective)To provide a method for the preparation of yunaconitine,an impurity of bulleyaconitine A,and explore the feasibility of using yunaconitine as an impurity reference substance.(Methods)The structure was confirmed by nuclear magnetic resonance spectroscopy and mass spectrometry,etc,the purity determination and quality control use HPLC.(Results)The white solid prepared was confirmed by structure confirma-tion and purity determination,and the purity was 99.51%and the yield was 58.1%.Bulleyaconitine A and its impurity yunaconitine has good line-arity in the concentration range of 0.08 to 1.0μg/mL and the relative correction factor is 0.95.(Conclusion)The yunaconitine prepared in this study can be used as a reference substance.In the study of the quality of the raw material and preparation of bulleyaconitine A,yunaconitine can be used as a known impurity for positioning and precise control,which improves the quality of bulleyaconitine A and ensures the safety of patients.关键词
草乌甲素/滇乌碱/制备方法/对照品/质量研究Key words
Bulleyaconitine A/Yunaconitine/Preparation Method/Reference Substance/Quality Study分类
医药卫生引用本文复制引用
付彬彬,龚爽,龚云麒,刘军锋..草乌甲素杂质——滇乌碱的制备与应用[J].云南化工,2024,51(5):35-38,4.
