中国光学（中英文）2024，Vol.17Issue(3)：512-520,9.DOI:10.37188/CO.2023-0237
基于超构透镜的微型头戴式荧光显微镜设计
Design of miniature head-mounted fluorescence microscope based on metalens
摘要
Abstract
The recent advent of miniature head-mounted fluorescence microscopes has revolutionized brain science research,enabling real-time imaging of neural activity in the brains of free-moving animals.However,the pursuit of miniaturization and reduced weight often results in a limited field of view,constrain-ing the number of neurons observable.While larger field-of-view systems exist,their increased weight can impede the natural behaviors of the subjects.Addressing these limitations,a novel design utilizing a metalens schematic is proposed.This approach offers the benefits of being ultra-light,ultra-thin,and capable of high-quality imaging.By deriving the aberration formula specific to hyperbolic phase metalens and using it as a foundation,a design for a miniature fluorescence microscope was developed.This microscope boasts a 4 mm×4 mm field of view and a numerical aperture(NA)of 0.14,effectively correcting seven primary aber-rations.The resulting prototype,weighing a mere 4.11 g,achieves a resolution of 7.8 μm across the entire field of view.This performance is sufficient to image neural activity in the brains of freely moving mice with single-cell resolution.关键词
微型荧光显微镜/超构透镜/光学设计/神经科学/像差理论Key words
miniature fluorescence microscope/metalens/optical design/neuron science/aberration theory分类
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张智淼,王承邈,谢冕,林雨,韩业明,邓永波,郭长亮,付强..基于超构透镜的微型头戴式荧光显微镜设计[J].中国光学（中英文）,2024,17(3):512-520,9.基金项目
中国科学院青年创新促进会资助(No.2021221) （No.2021221）
吉林省科技发展计划青年成长科技计划项目(No.20210508054RQ)Supported by Youth Innovation Promotion Association,CAS(No.2021221) （No.20210508054RQ）
Youth Growth Science and Tech-nology Program of Jilin Province Science and Technology Development Plan(No.20210508054RQ) （No.20210508054RQ）
