中国实用内科杂志2024，Vol.44Issue(5)：385-390,6.DOI:10.19538/j.nk2024050107
失代偿期乙肝肝硬化患者并发急性肾脏疾病的危险因素及其与临床预后的相关性分析
Risk factors of AKD in patients with decompensated hepatitis B cirrhosis and the correlation between AKD and clinical prognosis
摘要
Abstract
Objective To investigate the occurrence of acute kidney disease(AKD)in patients with decompensated hepatitis B cirrhosis,and to analyze its impact on the clinical prognosis of patients.Methods The inpatients with decompensated hepatitis B cirrhosis who first visited Lanzhou University First Hospital from January 2020 to December 2021 were screened and included.The clinical data at the time of initial admission were collected,and the patients were followed up for 90 days,and the patients survival was recorded.Results The incidence of AKD in patients with decompensated hepatitis B cirrhosis was 38.3％(51/133).Concurrent SBP[odds ratio(OR)12.251,95％CI 1.049-143.052)]and low eGFR(OR0.872,95％CI 0.824-0.922)were independent influencing factors of AKD in patients with decompensated hepatitis B cirrhosis.In terms of predicting adverse 90-day outcomes,concurrent AKD and high MELD scores were independent risk factors for 90-day death in patients with decompensated hepatitis B cirrhosis.Conclusion Concurrent SBP and renal function may be the key influencing factors of AKD in patients with decompensated hepatitis B cirrhosis,and the occurrence of AKD has an important impact on the short-term adverse outcomes of patients with decompensated hepatitis B cirrhosis.关键词
失代偿期/肝硬化/乙型肝炎/急性肾脏疾病/危险因素/预后Key words
decompensation/cirrhosis/hepatitis B/acute kidney disease/risk factors/prognosis分类
医药卫生引用本文复制引用
李琼,李俊峰,毛小荣..失代偿期乙肝肝硬化患者并发急性肾脏疾病的危险因素及其与临床预后的相关性分析[J].中国实用内科杂志,2024,44(5):385-390,6.基金项目
甘肃省自然科学基金(20JR5RA364) （20JR5RA364）
甘肃省重点研发计划(21YF5FA121) （21YF5FA121）
兰州大学第一医院院内基金(ldyyyn2020-02,ldyyyn2020-14) （ldyyyn2020-02,ldyyyn2020-14）
甘肃省感染肝病临床医学研究中心(21JR7RA392) （21JR7RA392）
