中国医科大学学报2024，Vol.53Issue(5)：446-450,457,6.DOI:10.12007/j.issn.0258-4646.2024.05.010
蛋黄油联合清热解毒汤外洗在肛周脓肿术后创面愈合中的应用
Application of egg yolk oil combined with Qingrejiedu decoction for external washing to promote wound healing after perianal abscess surgery
摘要
Abstract
Objective To explore the promoting effect of egg yolk oil combined with heat-clearing and detoxi-fying traditional Chinese medicine external washing on postoperative wound healing in patients with perianal abscesses based on growth factors in the wound granu-lation tissue.Methods Eighty patients with perianal abscesses admitted to our hospital from January 2023 to May 2023 were randomly divided into a control group and an observation group,with 40 patients in each group.Three days after surgery,the control group received routine treatment,such as external washing with heat-clearing and detoxifying Chinese herbal medicine and dressing changes with vase-line gauze.The observation group received additional treatment with egg yolk oil,and both groups were treated continuously for 7 days.The clinical efficacy,improvement in clinical symptoms,and wound recovery at different time points;serum inflammatory cytokines;and expression levels of wound granulation tissue-related factors were compared between the two groups.Results The total effective rate was higher in the observation group than the control group(95%vs.75%,P<0.05).The time of pruritus disappearance,decaying flesh,emer-gence of new epithelium,and healing were shorter in the observation group than in the control group(P<0.05).The pain degree,wound secretion,granulation morphology and surrounding tissue edema score of the observation group were significantly decreased at 7 and 10 days after surgery compared with the control group(P<0.05).Serum levels of interleukin(IL)-1β,IL-8,and tumor necrosis factor-α were lower in the observation group than the control group at 7 and 10 days after surgery(P<0.05).The levels of basic fibroblast growth factor,vascular endothelial cell growth factor,and transforming growth factor-βin wound granulation tissue were higher in the observation group than the control group at 7 and 10 days after surgery(P<0.05).Conclusion The external application of egg yolk oil combined with heat-clearing and detoxifying Chinese herbs can significantly improve the clinical symptoms of patients with perianal abscesses and promote wound healing,with significant therapeutic effects.This may be related to the inhibition of inflammatory cytokine expression and the promotion of wound granulation tissue growth factor expression.关键词
肛周脓肿/蛋黄油/生长因子/中药外洗/血清炎性细胞因子/创面愈合Key words
perianal abscess/egg yolk oil/growth factor/traditional Chinese medicine external washing/serum inflammatory cytokine/wound healing分类
医药卫生引用本文复制引用
吴士雄,温丽辉,刘满君,张磊,刘博,其徐韬..蛋黄油联合清热解毒汤外洗在肛周脓肿术后创面愈合中的应用[J].中国医科大学学报,2024,53(5):446-450,457,6.基金项目
河北省中医药管理局科研计划(2023057) （2023057）
