中山大学学报（医学科学版）2024，Vol.45Issue(3)：337-343,7.
索利那新治疗儿童特发性膀胱过度活动症的疗效分析
Efficacy of Solifenacin in Children with Idiopathic Overactive Bladder
摘要
Abstract
[Objective]To explore the efficacy of Solifenacin in the treatment of children with idiopathic overactive bladder(OAB).[Methods]The study included 67 children with idiopathic OAB treated in the urology clinic of our hospital from March 2022 to March 2023.After at least 2-week-long behavioral therapy showed no significant therapeutic effect,52 of the cases in the trial group were given oral Solifenacin 5 mg once daily and the other 15 cases in the control group con-tinued the behavioral therapy.The cases in trial group were subdivided into OAB-dry group(27 cases without urinary in-continence)and OAB-wet group(25 cases with urinary incontinence).The 3-day micturition diary,OAB Symptom Scores(OABSS)and the adverse reactions were recorded and analyzed before,at Weeks 2,4,8 and 12 after the treat-ment.[Results]Of all the 67 cases who completed a 3-month follow-up,44 were cured including 41 in the trial group and 3 in the control group,4 presented with adverse reactions.After the 3-month follow-up,the OABSS declined markedly in trial group than in control group(Z=4.524,P<0.001);the cure rates in trial group and control group are 78.8%and 20%respectively,with significant difference(χ2=15.367,P<0.001).At each follow-up,we found increased mean voided vol-ume(F=9.707,P<0.001),reduced mean voiding frequency during daytime(F=3.837,P=0.009)and decreased voiding urgency(χ2=482.835,P<0.001).After the 3-month follow-up,the cure rates in OAB-dry group and OAB-wet group are 81.5%and 76%respectively,with no significant difference(χ2=0.234,P=0.629).[Conclusions]In children with idiopath-ic OAB,oral Solifenacin 5 mg once daily could significantly increase mean voided volume,reduce mean voiding frequency during daytime,relieve symptoms of urinary urgency and lead to fewer adverse reactions,but is not significantly effective for the treatment of urinary incontinence in OAB-wet children.关键词
膀胱过度活动症/尿失禁/尿急/儿童/索利那新Key words
overactive bladder(OAB)/urinary incontinence/urinary urgency/children/Solifenacin分类
医药卫生引用本文复制引用
何萍,张晔,张殷,孙起航,尤龙,潮敏..索利那新治疗儿童特发性膀胱过度活动症的疗效分析[J].中山大学学报（医学科学版）,2024,45(3):337-343,7.基金项目
安徽省科技厅临床医学研究转化专项项目(202304295107020066) （202304295107020066）
