Lipid droplets in the nervous system:involvement in cell metabolic homeostasisOA
Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous system.Lipid droplet formation begins with the synthesis of neutral lipids in the endoplasmic reticulum.Previously,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous system.In addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress responses.Furthermore,lipid droplets exhibit specific functions in neurons and glial cells.Dysregulation of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system diseases.This review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and functions.Additionally,it will explore the association between lipid droplets and neurodegenerative disorders.Understanding the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.
Yuchen Zhang;Yiqing Chen;Cheng Zhuang;Jingxuan Qi;Robert Chunhua Zhao;Jiao Wang;
School of Life Sciences,Shanghai University,Shanghai,China School of Medicine,Shanghai University,Shanghai,ChinaSchool of Life Sciences,Shanghai University,Shanghai,ChinaSchool of Life Sciences,Shanghai University,Shanghai,China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing,China Center of Excellence in Tissue Engineering,Chinese Academy of Medical Sciences,Beijing,China Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy,Beijing,China
基础医学
Alzheimer''s diseaselipid droplet biogenesislipid dropletslipid metabolismnervous systemneurodegenerative disordersoxidative stressParkinson''s disease
《Neural Regeneration Research》 2025 (003)
P.740-750 / 11
funded by Basic Research Program of Shanghai,No.20JC1412200(to JW);the National Key Research and Development Program of China,No.2020YFA0113000(to RCZ)。
评论