内蒙古自治区赤峰市妊娠期妇女血清特异性甲状腺功能指标的检测及分析OACSTPCD

Objective:To explore the reference range of serum specific thyroid stimulating hormone(TSH)and free thyroxine(FT4)of different pregnancy periods among healthy pregnant women in Chifeng in order to provide diagnostic basis for thyroid diseases in pregnant women of the target area. Methods:The values of thyroid function test among 2 208 healthy pregnant women in Chifeng who were treated in Chifeng Maternity Hospital and Songshan Maternal and Child Health Hospital from 2018 to 2022 were analyzed and the gestation period was divided into the first trimester(0～13 weeks),the second trimester(14～27 weeks)and the third trimester(28～40 weeks)according to the test date.The 2.5th percentile(P2.5)was used as the lower limit of reference value and 97.5th percentile(P97.5)as the upper limit of the reference value to determine the reference range of specific TSH and FT4. Results:The age of the women was between 21 and 42 years old.The reference range of TSH was(0.16～4.21)U/L in the first trimester,(0.40～4.02)U/L in the second trimester and(0.48～4.47)U/L in the third trimester.The reference range of FT4 was(8.11～14.54)pmol/L in the first trimester,(6.82～12.74)pmol/L in the second trimester,and(7.08～14.41)pmol/L in the third trimester.The results of this study differed to some extent from the reference range of the Beckman manual used in the past and other reports. Conclusions:The establishment of the normal reference range of TSH and FT4 in different gestation period in Chifeng would benefit for preciously diagnosis and treatment of thyroid diseases and provide data support for reducing birth defects and eugenic in the target area.