大学化学2024，Vol.39Issue(5)：70-79,10.DOI:10.3866/PKU.DXHX202309090
抗击癌症之光——光动力治疗
Lighting the Way Against Cancer:Photodynamic Therapy
摘要
Abstract
Photodynamic therapy(PDT)emerges as a novel approach to treat tumors utilizing"photosensitizers"and"light".This method involves exposing the tumor site to specific wavelengths of light,activating photosensitizers concentrated in the tumor to generate highly oxidizing reactive oxygen species,ultimately dismantling the tumor.In comparison to surgery,chemotherapy,and radiation therapy,PDT boasts simplicity in operation,precise targeting,minimal invasiveness,lack of drug resistance,and the ability to trigger systemic immunity.While PDT has gained widespread adoption in developed nations,its promotion in China is still underway,hampered by a lack of public understanding.In response,we present a popular science experiment elucidating tumor-targeted photodynamic therapy using a laboratory-synthesized selenium-Rhodamine photosensitizer.The experiment encompasses enzyme activation of targeted photosensitizers,visual detection of singlet oxygen,and the photodynamic eradication of cancer cells.This experiment vividly illustrates the scientific principles behind targeted photodynamic therapy,enhancing public awareness of photodynamic cancer treatment.Such efforts are crucial for advancing the adoption of photodynamic therapy in our country,underscoring the pivotal role of chemistry in cancer treatment.The entire popular science experiment is straightforward,visually intuitive,and has demonstrated effective results in science outreach.关键词
光动力治疗/光敏剂/酶激活/单线态氧/可视化检测Key words
Photodynamic therapy/Photosensitizer/Enzyme activation/Singlet oxygen/Visual detection分类
社会科学引用本文复制引用
吕鑫,张洪星,段凯博,戴文惠,文智慧,郭炜,郝俊生..抗击癌症之光——光动力治疗[J].大学化学,2024,39(5):70-79,10.基金项目
山西省高等学校教学改革创新项目(J2021097,J2021099) （J2021097,J2021099）
国家自然科学基金(22277070) （22277070）
