日用化学工业（中英文）2024，Vol.54Issue(6)：691-697,7.DOI:10.3969/j.issn.2097-2806.2024.06.010
麝香草酚三甲氧基肉桂酸酯抑制黑色素生成、转移及AGEs合成的功效研究
Efficacy of thymol trimethoxycinnamate on melanin production,transfer and AGEs synthesis
陈海峰 1杨小玉 1余昊阳 2刘蕾 1李润夏 2何聪芬1
作者信息
- 1. 北京工商大学 轻工科学与工程学院 北京市植物资源研究开发重点实验室,北京 100048
- 2. 爱茉莉太平洋(上海)研发有限公司,上海 201801
- 折叠
摘要
Abstract
The whitening effect of thymol trimethoxycinnamate was studied based on skin cell model.CCK-8 method and cell state observation were used to detect the effect of thymol trimethoxycinnamate on the viability of B16-F10 cells.NaOH lysis method and dopa oxidation method were used to analyze the changes of melanin content and tyrosinase activity in B16-F10 cells.Cell scratch method and Transwell chamber method were used to determine the migration ability of B16-F10 cells.Fluorescence analysis was used to detect the changes of fluorescent AGEs content in the saccharification experiment in vitro.The results show that thymol trimethoxycinnamate has no significant effect on cell viability at or below 10 μg/mL,and has the highest inhibition rate on melanin synthesis,tyrosinase activity and cell migration at 10 μg/mL.The inhibition rate of fluorescent AGEs production in vitro is 97.75％at 200 μg/mL.The results show that thymol trimethoxycinnamate can obviously inhibit the formation of melanin and tyrosinase activity,and has a good whitening effect.Because of its good anti-saccharification ability,it can be used as a potential anti-aging material.关键词
麝香草酚三甲氧基肉桂酸酯/黑色素瘤细胞/美白/抗糖化Key words
thymol trimethoxycinnamate/melanocyte/whitening/anti-glycation分类
化学工程引用本文复制引用
陈海峰,杨小玉,余昊阳,刘蕾,李润夏,何聪芬..麝香草酚三甲氧基肉桂酸酯抑制黑色素生成、转移及AGEs合成的功效研究[J].日用化学工业（中英文）,2024,54(6):691-697,7.
