基于国医大师路志正"十八字诀"探讨慢性胃炎"炎癌转化"的中医药防治OA北大核心CSTPCD
Traditional Chinese medicine prevention and treatment of"inflammation cancer transformation"of chronic gastritis based on the perspective of"eighteen-character formula"from national medical master LU Zhizheng
"十八字诀"是国医大师路志正教授临证经验的集萃,对脾胃病的防治具有重要的指导意义.慢性胃炎"炎癌转化"是多因素、多阶段、多机制的复杂过程,基于路志正教授"十八字诀"探讨其病机和防治具有重要的理论和临床价值.在路志正教授"十八字诀"学术思想中,"持中央、运四旁"强调脾胃的核心地位,"怡情志、调升降"突出肝胃、肝脾、脾胃等脏腑关系,"顾润燥、纳化常"体现燥润相济、阴阳互助,恢复脾胃纳化功能的防治目的.在慢性胃炎"炎癌转化"的临床治疗中,当以脾胃为本,四旁运则五脏安;以气血为基,升降调则神机立;以阴阳为纲,润燥济则纳化常.本团队基于路志正教授学术思想及用药经验,研发了中药复方慢痞消,临床和基础研究表明其防治萎缩性胃炎癌前病变向胃癌恶性转化的疗效,进一步验证了路志正教授"十八字诀"的临床意义和价值.
The"eighteen-character formula"encapsulates the clinical wisdom of the national medical master,Prof.LU Zhizheng,and provides crucial guidance for the prevention and treatment of gastrointestinal disorders.The"inflammation cancer transformation"of chronic gastritis is a multifaceted process involving multiple factors,stages,and mechanisms.Drawing upon Prof.LU Zhizheng's"eighteen-character formula"to explore its pathogenesis and therapeutic strategies holds substantial theoretical and clinical value.Within Prof.LU Zhizheng's academic framework,the concept of"holding the center and moving the periphery"underscores the pivotal role of the spleen and stomach,"benefiting the emotions and smoothing the qi activity"highlights the relationship between liver and stomach,liver and spleen,spleen and stomach,and"mediating moisture and dryness,restoring the normal function of spleen and stomach"reflects the balance between dryness and moisture,mutual assistance between yin and yang,aiming to restore the normal digestive and transport functions of spleen and stomach.In the clinical management of"inflammation cancer transformation"in chronic gastritis,it is imperative to focus on the spleen and stomach as the foundation,ensuring the health of the five zang-fu organs by the activation of peripheral functions;to base treatment on the balance of qi and blood,establishing vital activities by the regulation of ascending and descending movements;and to adhere to the principles of yin and yang,ensuring the normal digestive and transportive functions of the spleen and stomach by the harmonization of moisture and dryness.Our team,inspired by Prof.LU Zhizheng's theoretical framework and medicinal expertise,has developed a compound herbal formula known as Manpi Xiao.Clinical and foundational research have shown that Manpi Xiao effectively prevents and treats the malignant progression of precancerous lesions to gastric cancer,further affirming the clinical significance and value of Prof.LU Zhizheng's"eighteen-character formula".
贾元萍;李园;丁霞
北京中医药大学东直门医院 北京 100700北京中医药大学国家中医体质与治未病研究院北京中医药大学中医学院
中医学
路志正十八字诀慢性胃炎炎癌转化
LU Zhizhengeighteen-character formulachronic gastritisinflammation cancer transformation
《北京中医药大学学报》 2024 (006)
792-796 / 5
国家重点研发计划项目(No.2018YFC1704106);北京市科技计划课题(No.Z221100007922047);国家自然科学基金面上项目(No.82374292) National Key R&D Program of China(No.2018YFC1704106)
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