肠脂肪酸结合蛋白在肠黏膜屏障损伤相关疾病中的作用研究进展OA北大核心CSTPCD

Intestinal tract is one of the largest organs in human body that is continuously exposed to the external environment,and it plays an important role as a physical and chemical barrier to protect the human body from pathogens.As an important part of the intestinal tract,the integrity of the intestinal mucosal barrier plays a key role in maintaining the intestinal microecological bal-ance.The destruction of the intestinal mucosal barrier can lead to the imbalance and translocation of intestinal flora,which is relat-ed to the occurrence and development of various diseases.Intestinal fatty acid binding protein(I-FABP)is one of the fatty acid-binding protein family,which exhibits specificity towards intestinal injury and will be released into the blood circulation rapidly when intestinal injury,ischemia,intestinal mucosal barrier damage and permeability increase occur.The elevated level of I-FABP is an important marker of intestinal injury,and intestinal dysfunction is often associated with many clinical diseases.This article mainly reviews the structural characteristics and function of I-FABP and its relationship with intestinal mucosal barrier related dis-eases.