海南医学院学报2024，Vol.30Issue(12)：939-946,8.DOI:10.13210/j.cnki.jhmu.temp.20231126.002
肠脂肪酸结合蛋白在肠黏膜屏障损伤相关疾病中的作用研究进展
Research progress on the role of intestinal fatty acid binding proteins in diseases associated with intestinal mucosal barrier damage
摘要
Abstract
Intestinal tract is one of the largest organs in human body that is continuously exposed to the external environment,and it plays an important role as a physical and chemical barrier to protect the human body from pathogens.As an important part of the intestinal tract,the integrity of the intestinal mucosal barrier plays a key role in maintaining the intestinal microecological bal-ance.The destruction of the intestinal mucosal barrier can lead to the imbalance and translocation of intestinal flora,which is relat-ed to the occurrence and development of various diseases.Intestinal fatty acid binding protein(I-FABP)is one of the fatty acid-binding protein family,which exhibits specificity towards intestinal injury and will be released into the blood circulation rapidly when intestinal injury,ischemia,intestinal mucosal barrier damage and permeability increase occur.The elevated level of I-FABP is an important marker of intestinal injury,and intestinal dysfunction is often associated with many clinical diseases.This article mainly reviews the structural characteristics and function of I-FABP and its relationship with intestinal mucosal barrier related dis-eases.关键词
肠脂肪酸结合蛋白/结构特征/功能/肠黏膜屏障/肠道损伤Key words
Intestinal fatty acid binding protein/Structural characteristics/Function/Intestinal mucosal barrier/Intestinal in-jury分类
医药卫生引用本文复制引用
苏小优,万燕,陈超超,蓝程..肠脂肪酸结合蛋白在肠黏膜屏障损伤相关疾病中的作用研究进展[J].海南医学院学报,2024,30(12):939-946,8.基金项目
This study was supported by National Natural Science Foundation of China(82060102)and Hainan Provincial Natural Science Foundation(821RC1116)国家自然科学基金(82060102) （82060102）
海南省自然科学基金(821RC1116) （821RC1116）
