激光生物学报2024，Vol.33Issue(3)：201-208,8.DOI:10.3969/j.issn.1007-7146.2024.03.002
叶酸在动物胚胎器官发育中的作用研究进展
Research on the Role of Folic Acid in the Development of Animal Embryonic Organs
摘要
Abstract
Folic acid,also known as vitamin B9,plays a key role in DNA synthesis,RNA transcription,homocysteine to me-thionine and cellular metabolism.Embryonic development is regulated by both environmental and genetic factors.Folic acid is an important nutrient for the normal development of animal embryonic organs.Maternal folic acid supplementation can reduce the risk of congenital organ dysplasia,such as heart,eyes,neural tube and kidney development abnormalities.In this study,we elucidates the involvement of folic acid transport,folic acid metabolism and the relationship between folic acid supplementation and epigenetic modifications in early embryonic organ development.In addition,we analyzed the effect of folic acid deficiency on the development of animal embryonic organs and the importance of folic acid supplementation during pregnancy,providing a theoretical basis for the prevention and treatment of abnormal embryonic organ development in the future.关键词
叶酸/胚胎器官发育/叶酸代谢/DNA甲基化/表观遗传修饰Key words
folate acid/embryonic organ development/folate acid metabolism/DNA methylation/epigenetic modifications分类
生物科学引用本文复制引用
曾欣,蔡晓妍,李芳..叶酸在动物胚胎器官发育中的作用研究进展[J].激光生物学报,2024,33(3):201-208,8.基金项目
国家自然科学基金青年科学基金项目(81800289) （81800289）
湖南省自然科学基金资助项目(2019JJ50394) （2019JJ50394）
湖南省教育厅科学研究重点项目(23A0082) （23A0082）
首届湖南省基础教育教学改革项目(Y20230592). （Y20230592）
