食品与发酵工业2024，Vol.50Issue(11)：327-335,9.DOI:10.13995/j.cnki.11-1802/ts.036727
单增李斯特菌毒力因子及调控机制研究进展
Research progress of virulence factors and regulatory mechanisms of Listeria monocytogenes
摘要
Abstract
Listeria monocytogenes,a gram-positive foodborne pathogen,demonstrates the ability to survive and thrive under adverse conditions,including low temperatures,high temperatures,and high osmotic pressure.Within the host organism,L.monocytogenes initial-ly parasitizes the gastrointestinal tract,subsequently traverses the intestinal barrier,and disseminates through the bloodstream to target or-gans,giving rise to a series of pathologies.This entire process is closely associated with the unique virulence factors and regulatory mecha-nisms of L.monocytogenes.This article begins with a thorough review and organization of the pivotal roles played by key virulence factors during L.monocytogenes infection,as well as the latest discoveries in this field.Subsequently,it introduces the virulence regulatory factor(PrfA)and the transcriptional regulatory factor(σB),with a specific focus on discussing the interplay of these regulatory factors within both the extracellular and intracellular environments of the host.Finally,a summarization and synthesis of the current novel virulence regu-latory factors are provided,offering essential insights to comprehensively understand infection mechanisms of L.monocytogenes and laying the groundwork for further precise prevention and control measures.关键词
单增李斯特菌/感染/毒力因子/调控因子Key words
Listeria monocytogenes/infection/virulence factors/regulatory factors引用本文复制引用
李钊,刘阳泰,李卓思,秦晓杰,王翔,董庆利..单增李斯特菌毒力因子及调控机制研究进展[J].食品与发酵工业,2024,50(11):327-335,9.基金项目
上海市农委2021年度上海市科技兴农技术创新项目(X2021-02-08-00-12-F00782) （X2021-02-08-00-12-F00782）
上海市农业领军人才项目(2022) （2022）
