食品工业科技2024，Vol.45Issue(13)：378-388,11.DOI:10.13386/j.issn1002-0306.2023080040
食品呈味肽的呈味机制及计算机辅助分析研究进展
Progress on the Tasting Mechanism and Computer Aided Analysis of Food Taste-Modulating Peptides
摘要
Abstract
Food taste-modulating peptides mainly interact with salt taste receptor ENaC,TRPV1 or TMC4,umami receptor T1R1/T1R3,sweet receptor T1R2/T1R3,bitter receptor T2R and kokumi receptor CaSR to induce PLCβ2/IP3 or cAMP/PKA pathway to achieve taste transduction.Computer aided analysis techniques such as molecular docking,dynamic simulation,virtual screening and deep learning can efficiently,accurately and widely identify and develop novel taste-modulating peptides,which can effectively promote the high-quality development of nutrition and health food industry.This paper aims to present the latest research progress in the field of taste-modulating peptides,including the human taste perception mechanism,the taste mechanism of food taste-modulating peptides,as well as computer aided analysis techniques.This provides ideas for cost reduction,efficiency enhancement,and subsequent in-depth research in the era of Big Compute and development of new taste-modulating peptide products in the field of food taste-modulating peptides development.关键词
呈味肽/味觉受体/呈味机制/分子对接/分子动力学模拟Key words
taste-modulating peptide/taste receptor/taste mechanism/molecular docking/molecular dynamic simulation分类
轻工纺织引用本文复制引用
杨动听,王晔洋,杨选,黄莎,李伟荣..食品呈味肽的呈味机制及计算机辅助分析研究进展[J].食品工业科技,2024,45(13):378-388,11.基金项目
丽水市重点研发计划项目香菇废弃菌柄高效利用关键技术开发与呈味肽产品研创(2023zdyf13). （2023zdyf13）
