110例强直性脊柱炎患者骨密度下降的特征及其危险因素OACSTPCD

Objective To analyze the clinical characteristics and risk factors of decreased bone mineral density(BMD)in pa-tients with ankylosing spondylitis(AS).Methods A total of 110 AS patients admitted to the 962nd Hospital of PLA Joint Logistics Support Force from January 2017 to November 2023 were reviewed.DXA method was used to measure BMD and the patients were di-vided into normal group(T-score>-1)and decreased group(T-score≤-1).The characteristics associated with decreased BMD were analyzed using univariate analysis,and the risk factors of decreased BMD were examined using multivariate logistic regression analysis.Results The median age of AS patients in Heilongjiang Province was 25.50(21.00,32.00)years,and the median disease duration was 1.00(0.70,3.00)years,with 109 male and 1 female.BMD was normal in 74 cases,and BMD decreased in 36 cases,including low bone mass in 32 cases and osteoporosis in 4 cases.A total of 62 cases received recombinant human tumor necrosis factor receptor type Ⅱ antibody fusion protein.Univariate analysis showed that age,disease course,CRP,and ESR were associated with BMD de-crease(P<0.05).Multivariate logistic analysis indicated that age(OR=1.14,95%CI:1.05～1.25),CRP(OR=1.09,95%CI:1.02～1.15),and ESR(OR=1.03,95%CI:1.00～1.07)were risk factors for BMD decrease,and recombinant human tumor necrosis factor re-ceptor type II antibody fusion protein(OR=0.27,95%CI:0.10～0.76)was a protective factor against BMD decrease.Conclusions Age,CRP and ESR are risk factors for BMD decrease in patients with AS,while recombinant human tumor necrosis fac-tor receptor type Ⅱ antibody fusion protein acts as a protective factor against BMD decrease.