医药导报2024，Vol.43Issue(7)：1017-1038,22.DOI:10.3870/j.issn.1004-0781.2024.07.001
儿童血栓性疾病防治药学实践指南
Pharmacy Practice Guidelines for the Prevention and Treatment of Thromboembolic Diseases in Children
摘要
Abstract
Objective In order to improve the rationalization of medication use for thrombosis prevention and treatment in children,the guideline aims to develop a comprehensive and practical guideline for pharmacy practice in the prevention and treatment of thromboembolic diseases in children.Through a systematic review of the available evidence-based medical evidence,specific recommendations for drug prevention and treatment are presented.Methods The World Health Organization(WHO)guideline development manual was used for the study design of the guideline.A systematic search and extensive collection of common medication problems for the prevention and treatment of thrombosis in children existed nationwide,and the Delphi method was used to research experts and determine the final clinical problems to be included.Then,a systematic literature search was conducted to comprehensively assess the existing original studies,systematic evaluations,and guidelines or consensus of professional organizations.Quality evaluation was conducted according to the grades of recommendations assessment,development and evaluation(GRADE)method,and consensus on the recommendations and level of evidence was reached again through the Delphi method,which ultimately led to the formation of the pharmacy practice guidelines for the prevention and treatment of thromboembolic diseases in children.Results A total of 29 clinical problems assessed by 74 experts in clinical pharmacy and clinical medicine were collected during the development of the guideline;15 clinical problems were screened through two rounds of questionnaires;and 15 clinical medication recommendations were developed under the supervision of two methodologists.Conclusion By comprehensively evaluating the feasibility and safety of clinical practice,the guideline will provide specific antithrombotic medication recommendations for pediatric healthcare professionals,which will help improve the prevention and treatment of thrombosis in children and promote more standardized and effective medical practice.关键词
儿童血栓/合理用药/血栓防治/药学实践指南Key words
Thrombosis in children/Rational medication use/Thrombosis prevention and treatment/Pharmacy practice guideline分类
医药卫生引用本文复制引用
四川省医学科学院·四川省人民医院,电子科技大学医学院,个体化药物治疗四川省重点实验室,中华医学会临床药学分会,中国心胸血管麻醉学会心血管药学分会,边原..儿童血栓性疾病防治药学实践指南[J].医药导报,2024,43(7):1017-1038,22.基金项目
国家重点研发计划(2020YFC2005506) （2020YFC2005506）
四川省科技厅自然科学基金(2022NSFSC0818) （2022NSFSC0818）
四川省药品监督管理局科技计划项目(2024012) （2024012）
个体化药物治疗四川省重点实验室开放课题(2021ZD01). （2021ZD01）
