集成磁共振技术在儿童孤独症谱系障碍伴或不伴精神发育迟缓中的应用研究OA北大核心CSTPCD

Objective:This study aimed to analyze the differences between T1 and T2 relaxation time in brain region a-mong three groups,children with autism spectrum disorder(ASD)with mental retardation(MR)(ASD with MR group),children with ASD(ASD group),and typically developing children(control group),using synthetic magnetic resonance imaging(SyMRI)se-quence on 3.0T MRI.The study also evaluated the diagnostic performance of T1 and T2 relaxation time in SyMRI.Methods:This study enrolled 60 subjects,including 20 children in ASD with MR group,20 children in ASD group,and 20 children in control group.All children underwent conventional and SyMRI sequences with a 3.0T MRI machine.T1 and T2 relaxation time in ten regions of interest in both white matter and gray matter were obtained using the MAGiC sequence.The study analyzed the correlations between T1 and T2 relaxation time in specific brain regions and the behavioral and developmental abilities of children.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic performance of T1 and T2 re-laxation time in distinguishing between ASD with or without MR.Results:There were statistically significant differences in the T1 relaxation time of the left thalamus among the ASD with MR group,ASD group,and control group(P<0.05).In the Gesell developmental scale,the T1 relaxation time of the left thalamus in the ASD with MR group was positively correlated with adaptive behavior scores(r=0.536,P<0.05).The T1 relaxation time of the left thalamus showed good diagnostic performance in distinguishing between ASD with or without MR(AUC>0.7).Conclusion:T1 relaxation time can effectively assess the abnormali-ties in the microstructural brain regions of children with ASD,whether accompanied with MR or not.It contributes to a better understanding of the pathological mechanisms underlying ASD with or without MR and provides diagnostic value in this context.