中国临床药理学与治疗学2024，Vol.29Issue(7)：785-791,7.DOI:10.12092/j.issn.1009-2501.2024.07.008
疫苗佐剂的作用机制及研究进展
Mechanism of action and research progress of vaccine adjuvants
摘要
Abstract
Vaccines are among the most effec-tive measures for preventing infectious diseases and play a crucial role in controlling the spread of these diseases.Adjuvants,serving as auxiliary com-ponents in vaccines,are indispensable in the vac-cine development process.Ideal adjuvants not only enhance the immune response,enabling the body to achieve optimal protective immunity but also play important roles in reducing the dosage of im-munogens and lowering vaccine production costs.To meet the demands of novel vaccines,many new types of adjuvants have been developed.However,there is still a lack of adjuvants that are safe,effec-tive,easy to prepare,highly pure,and suitable for a variety of vaccines in clinical settings.This article categorizes adjuvants and summarizes their mecha-nisms of action and characteristics,focusing on tra-ditional aluminum salt adjuvants and more modern lipid-based and nucleic acid-based adjuvants.The summary is based on a computer search of data-bases including PubMed,Embase,The Cochrane Li-brary,CNKI(China National Knowledge Infrastruc-ture),VIP Database,and Wanfang Database,using English search keywords such as Adjuvants,Vac-cine,Vaccine Adjuvant,aluminum salts,MF59,AS03,Toll-like receptor agonist,etc.,and corre-sponding Chinese search terms.The aim is to pro-vide references for the development and applica-tion of adjuvants.关键词
疫苗/佐剂/作用机制/免疫Key words
vaccines/adjuvants/mechanisms of action/immunity分类
医药卫生引用本文复制引用
张丽,宫建,卢畅,安明惠,王萌萌,宗晓郁,喻琳,冉卓灵,宋晶,李慧杰..疫苗佐剂的作用机制及研究进展[J].中国临床药理学与治疗学,2024,29(7):785-791,7.基金项目
中国医药教育协会项目(2023WSJSPGZXKT-27) （2023WSJSPGZXKT-27）
沈阳药科大学中青年教师事业发展支持计划立项(ZQN202205) （ZQN202205）
