中国药理学与毒理学杂志2024，Vol.38Issue(6)：473-480,8.DOI:10.3867/j.issn.1000-3002.2024.06.009
定量有害结局路径的构建方法及在毒理学中的应用研究进展
Advances in construction and applications of quantitative adverse outcome pathways in toxicology
摘要
Abstract
"Toxicity Testing in the 21st Century—A Vision and Strategy"proposed by the National Research Council of US has brought innovative directives and objectives for toxicity evaluation and risk assessment,pushing forward the next generation of toxicity testing and risk assessment.In this initiative,the concept of adverse outcome pathways(AOPs)has emerged as a prominent methodology,capturing the attention of toxicologists and researchers due to its promising applications in recent years.The quantitative AOP(qAOP)is an extension of the adverse outcome pathway,which is built upon the foundational qualitative adverse outcome pathway model and leverages mathematical frame-works to depict dose-response and/or response-response relationships.This article reviews the princi-ples and advancement surrounding qAOP,introduceds two prevalent methodologies for constructing qAOP,Bayesian network models and regression models,and demonstrates diverse applications of qAOP.Actual cases are used to underscore the transformative role of qAOP in contemporary toxicology and risk assessment practices.关键词
定量有害结局路径/毒性预测/风险评估/剂量响应关系Key words
quantitative adverse outcome pathway/toxicity prediction/risk assessment/dose-response relationship分类
医药卫生引用本文复制引用
李旻涛,陈锦瑶,练雪梅,霍娇,陈佳辉,姜蓓蓓,高杰,邹家丽,周倩如,严晓峰,罗书全,张华东..定量有害结局路径的构建方法及在毒理学中的应用研究进展[J].中国药理学与毒理学杂志,2024,38(6):473-480,8.基金项目
中国博士后科学基金(2022M710549) （2022M710549）
重庆市自然科学基金(cstc2021jcyj～msxmX0479) （cstc2021jcyj～msxmX0479）
重庆市博士后特别资助项目(2022CQBSHTB2065) China Postdoctoral Science Foundation(2022M710549) （2022CQBSHTB2065）
Natural Science Foundation of Chongqing(cstc2021jcyj-msxmX0479) （cstc2021jcyj-msxmX0479）
and Special Foundation of Chongqing Postdoctoral Program(2022CQBSHTB2065) （2022CQBSHTB2065）
