肥胖合并不孕症的诊治OA北大核心CSTPCD

Over the past few decades,the incidence of overweight and obesity have been increasing expo-nentially and have now become a global epidemic,leading to an increase in corresponding health payment costs.The obesity rate in women is significantly higher than that in men,and the relationship between fertility and obesity is complex,involving the hypothalamic-pituitary-ovarian axis,neuroendocrine system,and adipose tissue.The exact pathophysiological mechanism by which obesity reduces fertility is still unclear and may be multifactorial,including anovulation,insulin resistance,and changes in gonadotropin.There is also controversy over whether oocyte quality or endometrial receptivity play a greater role in obese and infertile patients.Although there is currently insufficient evi-dence to suggest that maternal weight loss interventions before pregnancy or assisted reproductive therapy can improve live birth rates.But it can be clarified that weight loss intervention can reduce the risk of IVF related complications and pregnancy complications,and increase the probability of healthy pregnancy and live birth.