Neuroprotective effects of resveratrol on retinal ganglion cells in glaucoma in rodents:A narrative reviewOA
Glaucoma,an irreversible optic neuropathy,primarily affects retinal ganglion cells(RGC)and causes vision loss and blindness.The damage to RGCs in glaucoma occurs by various mechanisms,including elevated intraocular pressure,oxidative stress,inflammation,and other neurodegenerative processes.As the disease progresses,the loss of RGCs leads to vision loss.Therefore,protecting RGCs from damage and promoting their survival are important goals in managing glaucoma.In this regard,resveratrol(RES),a polyphenolic phytoalexin,exerts antioxidant effects and slows down the evolution and progression of glaucoma.The present review shows that RES plays a protective role in RGCs in cases of ischemic injury and hypoxia as well as in ErbB2 protein expression in the retina.Additionally,RES plays protective roles in RGCs by promoting cell growth,reducing apoptosis,and decreasing oxidative stress in H_(2)O_(2)-exposed RGCs.RES was also found to inhibit oxidative stress damage in RGCs and suppress the activation of mitogen-activated protein kinase signaling pathways.RES could alleviate retinal function impairment by suppressing the hypoxia-i nducible factor-1 alpha/vascular endothelial growth factor and p38/p53 axes while stimulating the PI3K/Akt pathway.Therefore,RES might exert potential therapeutic effects for managing glaucoma by protecting RGCs from damage and promoting their survival.
Maryam Golmohammadi;Seyed Arash Aghaei Meibodi;Sulieman Ibraheem Shelash Al-Hawary;Jitendra Gupta;Ibrohim B.Sapaev;Mazin A.A.Najm;Marim Alwave;Mozhgan Nazifi;Mohammadreza Rahmani;Mohammad Yasin Zamanian;Gervason Moriasi;
School of Medicine,Shahid Beheshti University of Medical Sciences,Tehran,IranDepartment of Business Administration,Business School,Al al-Bayt University,Mafraq,JordanInstitute of Pharmaceutical Research,GLA University,Mathura,IndiaTashkent Institute of Irrigation and Agricultural Mechanization Engineers,Tashkent,Uzbekistan New Uzbekistan University,Tashkent,UzbekistanPharmaceutical Chemistry Department,College of Pharmacy,Al-Ayen University,Thi-Qar,IraqMedical Technical College,Al-Farahidi University,Baghdad,IraqDepartment of Neurology,Hamadan University of Medical Sciences,Hamadan,IranPhysiology-Pharmacology Research Center,Research Institute of Basic Medical Sciences,Rafsanjan University of Medical Sciences,Rafsanjan,Iran Department of Physiology and Pharmacology,School of Medicine,Rafsanjan University of Medical Sciences,Rafsanjan,IranNeurophysiology Research Center,Hamadan University of Medical Sciences,Hamadan,Iran Department of Pharmacology and Toxicology,School of Pharmacy,Hamadan University of Medical Sciences,Hamadan,IranDepartment of Medical Biochemistry,School of Medicine,College of Health Sciences,Mount Kenya University,Thika,Kenya
中医学
glaucomaischemic-reperfusion injuryoxidative stressresveratrolretinal ganglion cells
《Animal Models and Experimental Medicine》 2024 (003)
P.195-207 / 13
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