卒中后认知障碍患者认知功能的事件相关电位研究OACSTPCD

Objective To investigate the correlation between P300 latency at different electrodes and cognitive function in post-stroke cognitive impairment(PSCI)patients,providing experimental support for using P300 as an objective evaluation indica-tor of cognitive function.Methods This study included 46 patients diagnosed with PSCI from May to July 2023 at the Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine(PSCI group),and 20 control subjects matched for age,gender,and education level(control group).The control group was assessed with the Montreal cognitive assessment(MoCA),while the PSCI group was assessed with neuropsychological tests including MoCA,trail making test A(TMT-A),trail making test B(TMT-B),rivermead behavioural memory test-Ⅱ(RBMT-Ⅱ),and Rey-Osterrieth complex figure test(ROCFT).Both the control and PSCI groups completed the event-related potential P300 assessment within seven days of participation in the study.Results Compared with the control group,participants in the PSCI group showed significantly longer P300 latencies at nine electrodes(Fz,Cz,Pz,F3,C3,P3,F4,C4,and P4)(P<0.05).ROC analysis indicated a strong correlation between P300 latency at Cz and Pz and overall cognitive function prediction in PSCI patients(AUC>0.7).Further analysis revealed significant correlations between P300 latency at Pz and P4 with visuospatial/executive functions,P300 latency at Pz with orientation,P300 latency at Fz with attention,and P300 latency at Cz,Pz,and P4 with memory function(P<0.05).Conclusion The prolonged P300 latency in PSCI patients is significantly correlated with cognitive impairment.P300 latency at Fz,Cz,Pz,and P4 may serve as predictive indicators for overall cognitive function,visuospatial/executive functions,orientation,attention,and memory domains.These findings will further expand the assessment methods of cognitive functions in PSCI patients.